Cardiac allograft prolongation in mice treated with combined posttransplantation total-lymphoid irradiation and anti-L3T4 antibody therapy

Journal Article · Sat Apr 01 00:00:00 EST 1989 · Transplantation; (United States)

OSTI ID:6252840

Trager, D K; Banks, B A; Rosenbaum, G E; Holm, B I; Shizuru, J A; Strober, S; Fathman, C G

Neonatal cardiac allograft survival was examined in mice treated with anti-L3T4 antibody, posttransplantation total lymphoid irradiation (TLI) or a combination of both therapies. Independently, both posttransplantation TLI and short-course antibody treatment allowed minimal prolongation. However, synergistic prolongation in graft survival was observed with the combination (synergistic) therapy. Fluorescence-activated cell sorter analysis of peripheral blood lymphocytes from animals treated with combined anti-L3T4 and posttransplantation TLI additionally revealed ''synergy'' with respect to the degree of peripheral lymphocyte depletion.

• Research Organization: Stanford Univ. School of Medicine, CA (USA)
• OSTI ID: 6252840
• Journal Information: Transplantation; (United States), Vol. 47:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
RADIOSENSITIVITY EFFECTS
HEART
TRANSPLANTS
IMMUNITY
RADIOINDUCTION
LYMPHATIC SYSTEM
IRRADIATION
FLUORESCENCE
IMMUNOSUPPRESSION
LYMPHOCYTES
MICE
NEONATES
SURVIVAL TIME
SYNERGISM
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE CELLS
LEUKOCYTES
LUMINESCENCE
MAMMALS
MATERIALS
ORGANS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals