Program for PET image alignment: Effects on calculated differences in cerebral metabolic rates for glucose

Journal Article · Sat Dec 01 00:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6248776

Phillips, R L; London, E D; Links, J M; Cascella, N G ^[1]

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1. NIDA Addiction Research Center, Baltimore, MD (USA)

A program was developed to align positron emission tomography images from multiple studies on the same subject. The program allowed alignment of two images with a fineness of one-tenth the width of a pixel. The indications and effects of misalignment were assessed in eight subjects from a placebo-controlled double-blind crossover study on the effects of cocaine on regional cerebral metabolic rates for glucose. Visual examination of a difference image provided a sensitive and accurate tool for assessing image alignment. Image alignment within 2.8 mm was essential to reduce variability of measured cerebral metabolic rates for glucose. Misalignment by this amount introduced errors on the order of 20% in the computed metabolic rate for glucose. These errors propagate to the difference between metabolic rates for a subject measured in basal versus perturbed states.

• OSTI ID: 6248776
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:12; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
GLUCOSE
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OPTIMIZATION
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DATA COVARIANCES
IMAGES
ALDEHYDES
ALKALOIDS
ANESTHETICS
ANTIDEPRESSANTS
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CENTRAL NERVOUS SYSTEM
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DIAGNOSTIC TECHNIQUES
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HEXOSES
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
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550601* - Medicine- Unsealed Radionuclides in Diagnostics