X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons

Journal Article · Tue Dec 01 00:00:00 EST 1992 · Biochemical Genetics; (United States)

DOI:https://doi.org/10.1007/BF02399807· OSTI ID:6239667

VandeBerg, J L; Aivaliotis, M J; Samollow, P B ^[1]

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1. Southwest Foundation for Biomedical Research, San Antonio, TX (United States)

Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model. 61 refs., 1 fig., 4 tabs.

• OSTI ID: 6239667
• Journal Information: Biochemical Genetics; (United States), Vol. 30:11-12; ISSN 0006-2928
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ARTERIOSCLEROSIS
BIOLOGICAL MODELS
OXIDOREDUCTASES
RFLPS
X CHROMOSOME
INACTIVATION
BABOONS
CELL PROLIFERATION
GLUCOSE
HUMAN X CHROMOSOME
ALDEHYDES
ANIMALS
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CHROMOSOMES
DISEASES
ENZYMES
HETEROCHROMOSOMES
HEXOSES
HUMAN CHROMOSOMES
MAMMALS
MONKEYS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
SACCHARIDES
VASCULAR DISEASES
VERTEBRATES
550400* - Genetics