Erythrocyte survival in sheep exposed to ozone

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01610998· OSTI ID:6228800

Moore, G S; Calabrese, E J; Labato, F J

Erythrocyte survival studies in the Dorset ewe using chromium 51 were performed. The purpose of the study was to determine if ozone exposure produces decreased cell survival which may be the result of premature erythrocyte aging. This strain of sheep has an erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity that is very low, being comparable to human A-variants with G6PD deficiency. Ozone exposure may produce hemolytic effects in G6PD deficients more readily than in erythrocytes with normal activity. A decrease in hematocrit was observed in the ozone exposed groups. With respect to red cell destruction, ozone does not appear to act immediately, but rather there appears to be a delayed effect. At 0.25 ppM ozone, the group reached the 50% remaining level an average of 1 day sooner than the control group. There was no significant difference between control and exposed groups at the 0.50 ppM and 0.70 ppM levels. Also, the results demonstrate a net decrease in hematocrit which is greater for 0.25 ppM ozone than any other exposure level. (RJC)

• Research Organization: Univ. of Massachusetts, Amherst
• OSTI ID: 6228800
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 27:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ERYTHROCYTES
SURVIVAL TIME
OZONE
BIOLOGICAL EFFECTS
BLOOD COUNT
CHROMIUM 51
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
HEMOLYSIS
SHEEP
TIME DEPENDENCE
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
DATA
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LYSIS
MAMMALS
MATERIALS
NUCLEI
NUMERICAL DATA
PATHOLOGICAL CHANGES
RADIOISOTOPES
RUMINANTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551001 - Physiological Systems- Tracer Techniques