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Title: Lack of effect of drinking water barium on cardiovascular risk factors

Abstract

Higher cardiovascular mortality has been associated in a single epidemiological study with higher levels of barium in drinking water. The purpose of this study was to determine whether drinking water barium at levels found in some U.S. communities-alters the known risk factors for cardiovascular disease. Eleven healthy men completed a 10-week dose-response protocol in which diet was controlled. Other aspects of the subjects' lifestyles known to affect cardiac risk factors were controlled, and the barium content (as barium chloride) of the drinking water was varied from 0, to 5 ppm, to 10 ppm. Multiple blood and urine samples, morning and evening blood pressure measurements, and 48-hr electrocardiographic monitoring were performed at each dose of barium. There were no changes in morning or evening systolic or diastolic blood pressures, plasma cholesterol or lipoprotein or apolipoprotein levels, serum potassium or glucose levels, or urine catecholamine levels. There were no arrythmias related to barium exposure detected on continuous electrocardiographic monitoring. A trend was seen toward increased total serum calcium levels with exposure to barium, which was of borderline statistical significance and of doubtful clinical significance. In summary, drinking water barium at levels of 5 and 10 ppm did not appear to affect anymore » of the known modifiable cardiovascular risk factors.« less

Authors:
; ;  [1]
  1. Univ. of Cincinnati College of Medicine, OH (USA)
Publication Date:
OSTI Identifier:
6225687
Resource Type:
Journal Article
Journal Name:
Environmental Health Perspectives; (USA)
Additional Journal Information:
Journal Volume: 85; Journal ID: ISSN 0091-6765
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BARIUM COMPOUNDS; BIOLOGICAL EFFECTS; CARDIOVASCULAR DISEASES; RISK ASSESSMENT; DRINKING WATER; INGESTION; BLOOD PRESSURE; CALCIUM COMPOUNDS; ELECTROCARDIOGRAMS; HUMAN POPULATIONS; LIFE STYLES; MEN; ALKALINE EARTH METAL COMPOUNDS; ANIMALS; DIAGRAMS; DISEASES; HYDROGEN COMPOUNDS; INTAKE; MALES; MAMMALS; MAN; OXYGEN COMPOUNDS; POPULATIONS; PRIMATES; VERTEBRATES; WATER; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Wones, R G, Stadler, B L, and Frohman, L A. Lack of effect of drinking water barium on cardiovascular risk factors. United States: N. p., 1990. Web. doi:10.2307/3430694.
Wones, R G, Stadler, B L, & Frohman, L A. Lack of effect of drinking water barium on cardiovascular risk factors. United States. https://doi.org/10.2307/3430694
Wones, R G, Stadler, B L, and Frohman, L A. 1990. "Lack of effect of drinking water barium on cardiovascular risk factors". United States. https://doi.org/10.2307/3430694.
@article{osti_6225687,
title = {Lack of effect of drinking water barium on cardiovascular risk factors},
author = {Wones, R G and Stadler, B L and Frohman, L A},
abstractNote = {Higher cardiovascular mortality has been associated in a single epidemiological study with higher levels of barium in drinking water. The purpose of this study was to determine whether drinking water barium at levels found in some U.S. communities-alters the known risk factors for cardiovascular disease. Eleven healthy men completed a 10-week dose-response protocol in which diet was controlled. Other aspects of the subjects' lifestyles known to affect cardiac risk factors were controlled, and the barium content (as barium chloride) of the drinking water was varied from 0, to 5 ppm, to 10 ppm. Multiple blood and urine samples, morning and evening blood pressure measurements, and 48-hr electrocardiographic monitoring were performed at each dose of barium. There were no changes in morning or evening systolic or diastolic blood pressures, plasma cholesterol or lipoprotein or apolipoprotein levels, serum potassium or glucose levels, or urine catecholamine levels. There were no arrythmias related to barium exposure detected on continuous electrocardiographic monitoring. A trend was seen toward increased total serum calcium levels with exposure to barium, which was of borderline statistical significance and of doubtful clinical significance. In summary, drinking water barium at levels of 5 and 10 ppm did not appear to affect any of the known modifiable cardiovascular risk factors.},
doi = {10.2307/3430694},
url = {https://www.osti.gov/biblio/6225687}, journal = {Environmental Health Perspectives; (USA)},
issn = {0091-6765},
number = ,
volume = 85,
place = {United States},
year = {Sun Apr 01 00:00:00 EST 1990},
month = {Sun Apr 01 00:00:00 EST 1990}
}