Corticotropin releasing factor stimulates cAMP formation in pituitary corticotropic tumor cells

Journal Article · Mon Jan 23 00:00:00 EST 1984 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(84)90624-6· OSTI ID:6222763

Parenti, M; Cantalamessa, L; Catania, A; Reschini, E; Mueller, E E

Addition of corticotropin-releasing factor (CRF) to membranes from two ACTH-secreting pituitary tumors strikingly increased in a dose-dependent fashion adenylate cyclase (AC) activity. Stimulation of AC activity by CRF in membranes from non-tumoral tissue adjacent to tumoral corticotrophs was considerably lower, and was lacking in membranes from a growth hormone secreting tumor. These data correlated well with in vivo pre-surgery and post-surgery ACTH responsiveness to CRF of the tumor bearing patients. Basal AC activity was higher in pituitary adenomas than in non-tumoral adjacent tissue.

• Research Organization: Univ. of Milan, Italy
• OSTI ID: 6222763
• Journal Information: Life Sci.; (United States), Vol. 34:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
DIAGNOSIS
AMP
CHEMICAL ACTIVATION
RADIOASSAY
CORTICOSTEROIDS
BIOLOGICAL EFFECTS
PHOSPHORUS 32
ACTH
CUSHING SYNDROME
PATIENTS
PITUITARY GLAND
TUMOR CELLS
ADRENAL HORMONES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYDROXY COMPOUNDS
ISOTOPES
KETONES
LIGHT NUCLEI
NEOPLASMS
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORUS ISOTOPES
PITUITARY HORMONES
PREGNANES
RADIOISOTOPES
STEROID HORMONES
STEROIDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics