Review of the international symposium, sister chromatid exchanges: twenty-five years of experimental research

Conference · Sat Jan 01 00:00:00 EST 1983

OSTI ID:6220543

Tice, R R; Lambert, B; Morimoto, Kanehisa; Hollaender, A

The purpose of this symposium was to honor initial research at Brookhaven by bringing internationally recognized leaders in the fields of genetics, cytogenetics, carcinogenesis, mutagenesis, radiation biology, toxicology, and environmental health together into an open forum to present and discuss: (1) current knowledge of the induction and formation of SCEs and their relationship to other biological endpoints, including carcinogenesis, mutagenesis, transformation, clastogenesis, DNA damage and repair, and cellular toxicity; (2) the optimal strategies for the utilization of SCEs in genetic toxicology testing schemes involving in vitro and in vivo exposure situations; (3) the most valid statistical methods for analyzing SCE data obtained from cells in culture, from cells in intact organisms, and from cells in humans; (4) the relevance of SCEs as an indicator of human disease states, both inherited and acquired, and of progress in disease treatment; and (5) the use of SCEs as an indicator of human exposure to genotoxic agents and their relevance as a prognosticator of future adverse health outcomes. This report summarizes the presentations. 7 references. (ACR)

• Research Organization: Brookhaven National Lab., Upton, NY (USA); Karolinska Sjukhuset, Stockholm (Sweden). Dept. of Clinical Genetics; Tokyo Univ. (Japan). Faculty of Medicine; Council for Research Planning in Biological Sciences, Washington, DC (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6220543
• Report Number(s): BNL-35179; CONF-831261-3; ON: DE85000235
• Resource Relation: Conference: International symposium on sister chromatic exchange, Upton, NY, USA, 4 Dec 1983
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SISTER CHROMATID EXCHANGES
MEETINGS
BIOLOGICAL INDICATORS
CARCINOGENS
DNA REPAIR
MUTAGEN SCREENING
MUTAGENS
RADIOINDUCTION
TOXICITY
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMOSOMAL ABERRATIONS
DOCUMENT TYPES
MUTATIONS
RECOVERY
REPAIR
SCREENING
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