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Title: Review of the international symposium, sister chromatid exchanges: twenty-five years of experimental research

The purpose of this symposium was to honor initial research at Brookhaven by bringing internationally recognized leaders in the fields of genetics, cytogenetics, carcinogenesis, mutagenesis, radiation biology, toxicology, and environmental health together into an open forum to present and discuss: (1) current knowledge of the induction and formation of SCEs and their relationship to other biological endpoints, including carcinogenesis, mutagenesis, transformation, clastogenesis, DNA damage and repair, and cellular toxicity; (2) the optimal strategies for the utilization of SCEs in genetic toxicology testing schemes involving in vitro and in vivo exposure situations; (3) the most valid statistical methods for analyzing SCE data obtained from cells in culture, from cells in intact organisms, and from cells in humans; (4) the relevance of SCEs as an indicator of human disease states, both inherited and acquired, and of progress in disease treatment; and (5) the use of SCEs as an indicator of human exposure to genotoxic agents and their relevance as a prognosticator of future adverse health outcomes. This report summarizes the presentations. 7 references. (ACR)
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6220543
Report Number(s):
BNL-35179; CONF-831261-3
ON: DE85000235
DOE Contract Number:
AC02-76CH00016
Resource Type:
Conference
Resource Relation:
Conference: International symposium on sister chromatic exchange, Upton, NY, USA, 4 Dec 1983
Research Org:
Brookhaven National Lab., Upton, NY (USA); Karolinska Sjukhuset, Stockholm (Sweden). Dept. of Clinical Genetics; Tokyo Univ. (Japan). Faculty of Medicine; Council for Research Planning in Biological Sciences, Washington, DC (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SISTER CHROMATID EXCHANGES; MEETINGS; BIOLOGICAL INDICATORS; CARCINOGENS; DNA REPAIR; MUTAGEN SCREENING; MUTAGENS; RADIOINDUCTION; TOXICITY; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CHROMOSOMAL ABERRATIONS; DOCUMENT TYPES; MUTATIONS; RECOVERY; REPAIR; SCREENING 560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987); 560121 -- Radiation Effects on Cells-- External Source-- (-1987)