Relationship between lethal mutation yield and intake of ethylnitrosourea (ENU) in Drosophila melanogaster

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860060402· OSTI ID:6219711

Ayaki, T; Ohshima, K; Okumura, Y; Yoshikawa, I; Shiomi, T

To estimate the absorbed dose of N-ethyl-N-nitrosourea (ENU) ingested in Drosophila melanogaster, males were fed with sucrose solutions containing various concentrations of ENU plus /sup 3/H-labeled sucrose for 24 hr. Flies showed decreasing intakes with increase in ENU concentration when monitored by intake /sup 3/H radio-activity. Average absorbed doses of ENU were 0.064, 0.221, and 0.302 nmol, respectively, for the ENU concentrations of 0.03, 0.3, and 1.0 mM. Sex-linked recessive lethals were measured for males exposed to these sucrose solutions at three different ENU concentrations.

• Research Organization: Nagasaki Univ. School of Medicine, Japan
• OSTI ID: 6219711
• Journal Information: Environ. Mutagen.; (United States), Vol. 6:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LETHAL MUTATIONS
MUTATION FREQUENCY
NITROSOUREAS
GENETIC EFFECTS
INGESTION
DROSOPHILA
MUTAGENESIS
RECESSIVE MUTATIONS
TRITIUM COMPOUNDS
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
DIPTERA
FLIES
FRUIT FLIES
INSECTS
INTAKE
INVERTEBRATES
LABELLED COMPOUNDS
MUTATIONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
560304* - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)