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Title: Toxicological study of benzotrifuroxan

Abstract

The calculated acute oral LD/sub 50//sup 30/ (lethal dose for 50% of the animals occurring within 30 days after compound administration) value for Benzotrifuroxan (BTF) was 2884 mg/kg body weight in rats. The acute oral LD/sub 50//sup 30/ value in mice was greater than 5 g/kg. According to classical guidelines, this compound would be considered slightly toxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. The eye irritation study demonstrated BTF to be highly irritant when in contact with the eye, even to the point of causing corneal opacification and blindness. The sensitization study in the guinea pig did not show BTF to be deleterious in this regard.

Authors:
;
Publication Date:
Research Org.:
Los Alamos National Lab., NM (USA)
OSTI Identifier:
6217715
Report Number(s):
LA-9746-MS
ON: DE83013231
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZOFURANS; LETHAL DOSES; TOXICITY; CHEMICAL EXPLOSIVES; EYES; INGESTION; SENSITIVITY; SKIN; BODY; BODY AREAS; DOSES; EXPLOSIVES; FACE; FURANS; HEAD; HETEROCYCLIC COMPOUNDS; INTAKE; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; SENSE ORGANS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

London, J E, and Smith, D M. Toxicological study of benzotrifuroxan. United States: N. p., 1983. Web.
London, J E, & Smith, D M. Toxicological study of benzotrifuroxan. United States.
London, J E, and Smith, D M. 1983. "Toxicological study of benzotrifuroxan". United States.
@article{osti_6217715,
title = {Toxicological study of benzotrifuroxan},
author = {London, J E and Smith, D M},
abstractNote = {The calculated acute oral LD/sub 50//sup 30/ (lethal dose for 50% of the animals occurring within 30 days after compound administration) value for Benzotrifuroxan (BTF) was 2884 mg/kg body weight in rats. The acute oral LD/sub 50//sup 30/ value in mice was greater than 5 g/kg. According to classical guidelines, this compound would be considered slightly toxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. The eye irritation study demonstrated BTF to be highly irritant when in contact with the eye, even to the point of causing corneal opacification and blindness. The sensitization study in the guinea pig did not show BTF to be deleterious in this regard.},
doi = {},
url = {https://www.osti.gov/biblio/6217715}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Apr 01 00:00:00 EST 1983},
month = {Fri Apr 01 00:00:00 EST 1983}
}

Technical Report:
Other availability
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