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Title: (In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine)

The overall goal of our research remains to investigate the mutagenic and clastogenic effects of exposure to low levels of ionizing radiation to human lymphocytes. We are utilizing these endpoints to examine sets of individuals who have been exposed to ionizing radiation as a result of medical procedures. The cohorts we are studying include: nuclear medicine technicians, two set of nuclear medicine patients, sets of controls and a new set of Hodgkins disease patients. Emphasis in the second year has been on measurements of chromosome aberrations in patients imaged with thallium-201, mutant frequencies in patients imaged with technetium-99, mutant frequencies in nuclear medicine technicians and physical therapists, and mutant frequencies in patients treated for Hodgkins disease with radiotherapy. The progress in these areas is described in this report in more detail.
Publication Date:
OSTI Identifier:
6217102
Report Number(s):
DOE/ER/60745-3
ON: DE91005587
DOE Contract Number:
FG02-89ER60745
Resource Type:
Technical Report
Research Org:
Harvard Univ., Boston, MA (USA). School of Public Health
Sponsoring Org:
DOE/ER
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; GENE MUTATIONS; LYMPHOCYTES; BIOLOGICAL RADIATION EFFECTS; TECHNETIUM 99; DIAGNOSTIC USES; THALLIUM 201; IMAGE PROCESSING; IONIZING RADIATIONS; MUTAGENESIS; NUCLEAR MEDICINE; PATIENTS; PROGRESS REPORT; RADIATION INDUCED MUTANTS; TRACER TECHNIQUES; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DOCUMENT TYPES; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LEUKOCYTES; MATERIALS; MEDICINE; MUTANTS; MUTATIONS; NUCLEI; ODD-EVEN NUCLEI; PROCESSING; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SOMATIC CELLS; TECHNETIUM ISOTOPES; THALLIUM ISOTOPES; USES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics