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Title: Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases

Abstract

The beta-adrenergic receptor binding sites on peripheral lymphocytes in children with bronchial asthma (n = 16) and seasonal allergic rhinitis (n = 8) were examined in comparison with normal controls (n = 18) by means of /sup 124/I-cyanopindolol. The number of beta-adrenergic receptors was significantly lower in the asthmatic group (858 +/- 460/lymphocyte) than in the controls (1564 +/- 983/lymphocyte). The value (1891 +/- 1502/lymphocyte in children with allergic rhinitis was slightly higher than that in healthy controls. Of the 24 patients suffering from allergic diseases of the lower or upper airways, the bronchial histamine provocation test was performed in 21; 16 gave positive results, while 5 were negative. No difference in beta-adrenergic receptor count was found between the histamine-positive and negative patients. Neither was there any correlation between the number of beta-adrenergic receptors and the high (16/24) and low (8/24) serum IgE concentrations found in allergic patients. The significant decrease in beta-adrenergic receptor count in asthmatic children lends support to Szentivanyi's concept. Further qualitative and quantitative analysis of lymphocyte beta-adrenergic receptors may provide an individual approach to the treatment of bronchial asthma with beta-sympathomimetic drugs.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Albert Szent-Gyoergyi Univ. Medical School, Szeged (Hungary)
OSTI Identifier:
6213281
Resource Type:
Journal Article
Journal Name:
Pediatr. Pulmonol.; (United States)
Additional Journal Information:
Journal Volume: 5:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHILDREN; RESPIRATORY SYSTEM DISEASES; PATHOGENESIS; SYMPATHOMIMETICS; RECEPTORS; ASTHMA; IODINE 124; LYMPHOCYTES; PATIENTS; TRACER TECHNIQUES; AGE GROUPS; ANIMAL CELLS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LEUKOCYTES; MATERIALS; MEMBRANE PROTEINS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; SOMATIC CELLS; 550901* - Pathology- Tracer Techniques

Citation Formats

Bittera, I, Gyurkovits, K, Falkay, G, Eck, E, and Koltai, M. Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases. United States: N. p., 1988. Web. doi:10.1002/ppul.1950050202.
Bittera, I, Gyurkovits, K, Falkay, G, Eck, E, & Koltai, M. Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases. United States. https://doi.org/10.1002/ppul.1950050202
Bittera, I, Gyurkovits, K, Falkay, G, Eck, E, and Koltai, M. 1988. "Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases". United States. https://doi.org/10.1002/ppul.1950050202.
@article{osti_6213281,
title = {Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases},
author = {Bittera, I and Gyurkovits, K and Falkay, G and Eck, E and Koltai, M},
abstractNote = {The beta-adrenergic receptor binding sites on peripheral lymphocytes in children with bronchial asthma (n = 16) and seasonal allergic rhinitis (n = 8) were examined in comparison with normal controls (n = 18) by means of /sup 124/I-cyanopindolol. The number of beta-adrenergic receptors was significantly lower in the asthmatic group (858 +/- 460/lymphocyte) than in the controls (1564 +/- 983/lymphocyte). The value (1891 +/- 1502/lymphocyte in children with allergic rhinitis was slightly higher than that in healthy controls. Of the 24 patients suffering from allergic diseases of the lower or upper airways, the bronchial histamine provocation test was performed in 21; 16 gave positive results, while 5 were negative. No difference in beta-adrenergic receptor count was found between the histamine-positive and negative patients. Neither was there any correlation between the number of beta-adrenergic receptors and the high (16/24) and low (8/24) serum IgE concentrations found in allergic patients. The significant decrease in beta-adrenergic receptor count in asthmatic children lends support to Szentivanyi's concept. Further qualitative and quantitative analysis of lymphocyte beta-adrenergic receptors may provide an individual approach to the treatment of bronchial asthma with beta-sympathomimetic drugs.},
doi = {10.1002/ppul.1950050202},
url = {https://www.osti.gov/biblio/6213281}, journal = {Pediatr. Pulmonol.; (United States)},
number = ,
volume = 5:2,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}