skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Dose equivalence for high-dose-rate to low-dose-rate intracavitary irradiation in the treatment of cancer of the uterine cervix

Abstract

By comparing the incidence of major radiation injury, we estimated doses clinically equivalent for high-dose-rate (HDR) to conventional low-dose-rate (LDR) intracavitary irradiation in patients with Stages IIb and IIIb cancer of the uterine cervix. We reviewed a total of 300 patients who were treated with external beam therapy to the pelvis (50 Gy in 5 weeks) followed either by low-dose-rate (253 patients) or high-dose-rate (47 patients) intracavitary treatment. The high-dose-rate intracavitary treatment was given 5 Gy per session to point A, 4 fractions in 2 weeks, with a total dose of 20 Gy. The low-dose-rate treatment was given with one or two application(s) delivering 11-52 Gy to the point A. The local control rates were similar in both groups. The incidence of major radiation injury requiring surgical intervention were 5.1% (13/253) and 4.3% (2/47) for low-dose-rate and high-dose-rate groups, respectively. The 4.3% incidence corresponded to 29.8 Gy with low-dose-rate irradiation, thus, it was concluded that the clinically equivalent dose for high-dose-rate irradiation was approximately 2/3 (20/29.8) of the dose used in low-dose-rate therapy.

Authors:
; ; ; ; ;  [1]
  1. National Cancer Center Hospital, Tokyo (Japan)
Publication Date:
OSTI Identifier:
6210802
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics; (USA)
Additional Journal Information:
Journal Volume: 19:6; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; RADIOTHERAPY; UTERUS; DOSE EQUIVALENTS; IRRADIATION PROCEDURES; PATIENTS; RADIATION DOSES; SURVIVAL CURVES; BODY; DISEASES; DOSES; FEMALE GENITALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Akine, Y, Tokita, N, Ogino, T, Kajiura, Y, Tsukiyama, I, and Egawa, S. Dose equivalence for high-dose-rate to low-dose-rate intracavitary irradiation in the treatment of cancer of the uterine cervix. United States: N. p., 1990. Web. doi:10.1016/0360-3016(90)90365-Q.
Akine, Y, Tokita, N, Ogino, T, Kajiura, Y, Tsukiyama, I, & Egawa, S. Dose equivalence for high-dose-rate to low-dose-rate intracavitary irradiation in the treatment of cancer of the uterine cervix. United States. https://doi.org/10.1016/0360-3016(90)90365-Q
Akine, Y, Tokita, N, Ogino, T, Kajiura, Y, Tsukiyama, I, and Egawa, S. 1990. "Dose equivalence for high-dose-rate to low-dose-rate intracavitary irradiation in the treatment of cancer of the uterine cervix". United States. https://doi.org/10.1016/0360-3016(90)90365-Q.
@article{osti_6210802,
title = {Dose equivalence for high-dose-rate to low-dose-rate intracavitary irradiation in the treatment of cancer of the uterine cervix},
author = {Akine, Y and Tokita, N and Ogino, T and Kajiura, Y and Tsukiyama, I and Egawa, S},
abstractNote = {By comparing the incidence of major radiation injury, we estimated doses clinically equivalent for high-dose-rate (HDR) to conventional low-dose-rate (LDR) intracavitary irradiation in patients with Stages IIb and IIIb cancer of the uterine cervix. We reviewed a total of 300 patients who were treated with external beam therapy to the pelvis (50 Gy in 5 weeks) followed either by low-dose-rate (253 patients) or high-dose-rate (47 patients) intracavitary treatment. The high-dose-rate intracavitary treatment was given 5 Gy per session to point A, 4 fractions in 2 weeks, with a total dose of 20 Gy. The low-dose-rate treatment was given with one or two application(s) delivering 11-52 Gy to the point A. The local control rates were similar in both groups. The incidence of major radiation injury requiring surgical intervention were 5.1% (13/253) and 4.3% (2/47) for low-dose-rate and high-dose-rate groups, respectively. The 4.3% incidence corresponded to 29.8 Gy with low-dose-rate irradiation, thus, it was concluded that the clinically equivalent dose for high-dose-rate irradiation was approximately 2/3 (20/29.8) of the dose used in low-dose-rate therapy.},
doi = {10.1016/0360-3016(90)90365-Q},
url = {https://www.osti.gov/biblio/6210802}, journal = {International Journal of Radiation Oncology, Biology and Physics; (USA)},
issn = {0360-3016},
number = ,
volume = 19:6,
place = {United States},
year = {Sat Dec 01 00:00:00 EST 1990},
month = {Sat Dec 01 00:00:00 EST 1990}
}