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Title: Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster

Abstract

The acute inhalation toxicity of 3-methylfuran (3MF) was investigated in SPF Fischer-derived and CD/CR rats, and golden Syrian hamsters by determination of the 2-week LC/sub 50/, and by histologic examination of animals killed 1, 3, and 14 days following a 1-hr exposure to 148 and 322 ..mu..mole 3MF/liter for CD/CR rats and hamsters, respectively. The Fischer-derived rat was more sensitive to 3MF-induced lethality than the CD/CR rat with an LC/sub 50/ in the male rat of 81 ..mu..mole/liter-1 hr as compared to 222 ..mu..mole/liter-1hr. No sex difference was found. The hamster was relatively resistant with no lethality at 322 ..mu..mole 3MF/liter-2 hr. Pulmonary damage was present in both species. In the hamster, selective necrosis of nonciliated bronchiolar epithelial (Clara) cells was seen at 1 day with virtually complete regeneration by 14 days whereas in the rat the bronchiolar epithelial damage was more extensive and was followed by scattered peribronchiolar fibrosis and epithelial mucous metaplasia suggestive of ''small airway disease'' of man. Relatively selective 3MF-induced necrosis of olfactory epithelium occurred in the nasal mucosa of both species. Resolution of this lesion was seen by 14 days in the hamster. In the rat, however, the necrosis was much more extensive and wasmore » followed by partially occlusive fibrosis of the nasal cavity as seen at 14 days. 3MF also induced centrilobular hepatic necrosis in both species. In the rat, lymphocyte necrosis in the thymus and spleen, and esophageal necrosis was also seen.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN
OSTI Identifier:
6208383
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Journal Article
Journal Name:
Exp. Mol. Pathol.; (United States)
Additional Journal Information:
Journal Volume: 39
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FURANS; TOXICITY; ANIMAL CELLS; BRONCHI; COMPARATIVE EVALUATIONS; EPITHELIUM; ESOPHAGUS; FIBROSIS; HAMSTERS; INHALATION; LIVER; LYMPHOCYTES; NECROSIS; PATHOLOGICAL CHANGES; PHARYNX; RATS; SENSITIVITY; SPLEEN; THYMUS; ANIMAL TISSUES; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DIGESTIVE SYSTEM; GLANDS; HETEROCYCLIC COMPOUNDS; INTAKE; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Haschek, W M, Morse, C C, Boyd, M R, Hakkinen, P J, and Witschi, H P. Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster. United States: N. p., 1983. Web. doi:10.1016/0014-4800(83)90063-1.
Haschek, W M, Morse, C C, Boyd, M R, Hakkinen, P J, & Witschi, H P. Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster. United States. https://doi.org/10.1016/0014-4800(83)90063-1
Haschek, W M, Morse, C C, Boyd, M R, Hakkinen, P J, and Witschi, H P. 1983. "Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster". United States. https://doi.org/10.1016/0014-4800(83)90063-1.
@article{osti_6208383,
title = {Pathology of acute inhalation exposure to 3-methylfuran in the rat and hamster},
author = {Haschek, W M and Morse, C C and Boyd, M R and Hakkinen, P J and Witschi, H P},
abstractNote = {The acute inhalation toxicity of 3-methylfuran (3MF) was investigated in SPF Fischer-derived and CD/CR rats, and golden Syrian hamsters by determination of the 2-week LC/sub 50/, and by histologic examination of animals killed 1, 3, and 14 days following a 1-hr exposure to 148 and 322 ..mu..mole 3MF/liter for CD/CR rats and hamsters, respectively. The Fischer-derived rat was more sensitive to 3MF-induced lethality than the CD/CR rat with an LC/sub 50/ in the male rat of 81 ..mu..mole/liter-1 hr as compared to 222 ..mu..mole/liter-1hr. No sex difference was found. The hamster was relatively resistant with no lethality at 322 ..mu..mole 3MF/liter-2 hr. Pulmonary damage was present in both species. In the hamster, selective necrosis of nonciliated bronchiolar epithelial (Clara) cells was seen at 1 day with virtually complete regeneration by 14 days whereas in the rat the bronchiolar epithelial damage was more extensive and was followed by scattered peribronchiolar fibrosis and epithelial mucous metaplasia suggestive of ''small airway disease'' of man. Relatively selective 3MF-induced necrosis of olfactory epithelium occurred in the nasal mucosa of both species. Resolution of this lesion was seen by 14 days in the hamster. In the rat, however, the necrosis was much more extensive and was followed by partially occlusive fibrosis of the nasal cavity as seen at 14 days. 3MF also induced centrilobular hepatic necrosis in both species. In the rat, lymphocyte necrosis in the thymus and spleen, and esophageal necrosis was also seen.},
doi = {10.1016/0014-4800(83)90063-1},
url = {https://www.osti.gov/biblio/6208383}, journal = {Exp. Mol. Pathol.; (United States)},
number = ,
volume = 39,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1983},
month = {Sat Jan 01 00:00:00 EST 1983}
}