Cerebral perfusion imaging with iodine 123-labeled amines

Holman, B L; Hill, T C; Polak, J F; Lee, R G; Royal, H D; O'Leary, D H

doi:10.1001/archneur.1984.04050210058015

Title: Cerebral perfusion imaging with iodine 123-labeled amines

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Abstract

Two amines, N-isopropyl p-iodoamphetamine and N,N,N'-trimethyl-N'-(2-hydroxyl-3-methyl-5-iodobenzyl)-1,3-prop anediamine, have been labeled with iodine 123. The brain uptake of these radioactive tracers is proportional to cerebral blood flow. These tracers are retained in the brain for a sufficiently long time so that imaging can be performed with standard, readily available instrumentation. Transaxial tomography with amines is useful in acute cerebral infarction, in which the x-ray computed tomographic scan may be normal for several days after onset of symptoms while the uptake of radioisotope-labeled amines will be altered immediately after the onset of the stroke. It is also useful in examining patients with cerebral vascular disease and in the preoperative examination of patients with partial epilepsy.

Authors:: Holman, B L; Hill, T C; Polak, J F; Lee, R G; Royal, H D; O'Leary, D H

Publication Date:: Mon Oct 01 00:00:00 EDT 1984

Research Org.:: Department of Radiology, Harvard Medical School, Boston, MA

OSTI Identifier:: 6195989

Resource Type:: Journal Article

Journal Name:: Arch. Neurol.; (United States)

Additional Journal Information:: Journal Volume: 41:10

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; TOMOGRAPHY; IODINE 123; DIAGNOSTIC USES; AMINES; BLOOD FLOW; IMAGES; LABELLED COMPOUNDS; PERFUSED ORGANS; RADIOISOTOPE SCANNING; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Holman, B L, Hill, T C, Polak, J F, Lee, R G, Royal, H D, and O'Leary, D H. Cerebral perfusion imaging with iodine 123-labeled amines.  United States: N. p., 1984. 
        Web.  doi:10.1001/archneur.1984.04050210058015.

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                    Holman, B L, Hill, T C, Polak, J F, Lee, R G, Royal, H D, & O'Leary, D H. Cerebral perfusion imaging with iodine 123-labeled amines.  United States.  https://doi.org/10.1001/archneur.1984.04050210058015

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                    Holman, B L, Hill, T C, Polak, J F, Lee, R G, Royal, H D, and O'Leary, D H. 1984.  
        "Cerebral perfusion imaging with iodine 123-labeled amines".  United States.  https://doi.org/10.1001/archneur.1984.04050210058015.

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@article{osti_6195989,

  title        = {Cerebral perfusion imaging with iodine 123-labeled amines},

  author       = {Holman, B L and Hill, T C and Polak, J F and Lee, R G and Royal, H D and O'Leary, D H},

  abstractNote = {Two amines, N-isopropyl p-iodoamphetamine and N,N,N'-trimethyl-N'-(2-hydroxyl-3-methyl-5-iodobenzyl)-1,3-prop anediamine, have been labeled with iodine 123. The brain uptake of these radioactive tracers is proportional to cerebral blood flow. These tracers are retained in the brain for a sufficiently long time so that imaging can be performed with standard, readily available instrumentation. Transaxial tomography with amines is useful in acute cerebral infarction, in which the x-ray computed tomographic scan may be normal for several days after onset of symptoms while the uptake of radioisotope-labeled amines will be altered immediately after the onset of the stroke. It is also useful in examining patients with cerebral vascular disease and in the preoperative examination of patients with partial epilepsy.},

  doi          = {10.1001/archneur.1984.04050210058015},

  url          = {https://www.osti.gov/biblio/6195989},
  journal      = {Arch. Neurol.; (United States)},
number       = ,

  volume       = 41:10,

  place        = {United States},

  year         = {Mon Oct 01 00:00:00 EDT 1984},

  month        = {Mon Oct 01 00:00:00 EDT 1984}

}

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