Whole-body nitrogen and tyrosine metabolism in surgical patients receiving branched-chain amino acid solutions
Fifteen patients undergoing gastric bypass surgery for morbid obesity received preoperatively a standard crystalline amino acid solution containing 15.6% branched-chain amino acids. During the first five postoperative days, the patients were randomized to receive one of three amino acid solutions of different branched-chain amino acid content. Whole-body amino acid appearance and oxidation were estimated using a continuous intravenous infusion of L-(U-/sup 14/C)-tyrosine preoperatively and on the third postoperative day. This study suggests that an adequate nitrogen intake of a balanced amino acid mixture, as well as a solution enriched with branched-chain amino acids, maintains protein homeostasis and supports protein synthesis similarly in well-nourished patients following major abdominal surgery. A diet containing only branched-chain amino acids in isomolar ratios was as effective at maintaining protein retention and whole-body protein synthesis and albumin renewal postoperatively when compared with a standard amino acid formula.
- Research Organization:
- New England Deaconess Hospital/Harvard Medical School, Boston, MA
- OSTI ID:
- 6193552
- Journal Information:
- Arch. Surg. (Chicago); (United States), Vol. 12
- Country of Publication:
- United States
- Language:
- English
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