Immunization of baboons with Schistosoma mansoni cercariae attenuated by gamma irradiation

Journal Article · Fri Jun 26 00:00:00 EDT 1981 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7233238· OSTI ID:6189183

Stek, M Jr; Minard, P; Dean, D A; Hall, J E

Studies on the efficacy of a vaccine against schistosomiasis in young baboons (Papio anubis) disclosed that immunization with Schistosoma mansoni cercariae attenuated by gamma irradiation induced significant protection against subsequent infection with normal, viable S. mansoni cercariae. Such immunization resulted in reduced worm burdens (70%) and egg excretion rates (82%). These results support immunization as a potential method for schistosomiasis control.

• Research Organization: Naval Medical Research Inst., Bethesda, MD
• OSTI ID: 6189183
• Journal Information: Science (Washington, D.C.); (United States), Vol. 212
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL KILLING
RADIOINDUCTION
SCHISTOSOMA
BIOLOGICAL RADIATION EFFECTS
VACCINES
APES
GAMMA RADIATION
IMMUNITY
ANIMALS
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
HELMINTHS
IONIZING RADIATIONS
MAMMALS
PLATYHELMINTHS
PRIMATES
RADIATION EFFECTS
RADIATIONS
TREMATODES
VERTEBRATES
560134* - Radiation Effects on Microorganisms- Vaccine Preparation & Other Applications- (-1987)