Criteria for electric field bioeffects investigations and risk assessment
Most of the research on biological effects of electric fields (EF) has been done with small rodents that have many physical and physiological attributes significantly different from those of man. In making extrapolations from animal data to man we must be particularly cognizant of the limitations and pitfalls in the use of animal experimentation data. Many factors must be considered in the design of experiments using organisms other than man as a test subject. These include the species, strain, sex, age of the animal, the methods of caring for the test animals, the animals' feeding patterns, the roles of seasonal and circadian rhythms, biological drifts, temperature and humidity. The reliability of laboratory studies using experimental animal models depends on the following considerations: (1) the selection of the animal model with consideration of its cognitive limits, (2) scaling factors associated with the nature of the field in the laboratory investigation of the biological processes using animal models, and (3) the methods by which the extrapolation of the data from the animal models relate to human studies.
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 6185836
- Report Number(s):
- DOE/EV/03490-2250; CONF-830626-1; ON: DE83010193
- Resource Relation:
- Conference: IEEE/ESMO conference, Atlanta, GA, USA, 9 Jun 1983
- Country of Publication:
- United States
- Language:
- English
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