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Title: Different radiosensitivities of mast-cell precursors in the bone marrow and skin of mice

Although tissue mast cells are derived from the bone marrow, some descendants of bone marrow-derived precursors retain the ability to proliferate and differentiate into mast cells even after localization in the skin. The purpose of the present study was to determine the D0 values for mast-cell precursors in the bone marrow and those localized in the skin. Bone marrow cells were removed from (WB X C57BL/6)F1-+/+ mice after various doses of irradiation and injected into the skin of the congenic W/Wv mice which were genetically without mast cells. Radiosensitivity of mast-cell precursors in the bone marrow was evaluated by determining the proportion of the injection sites at which mast cells did not appear. For the assay of the radiosensitivity of mast-cell precursors localized in the skin, pieces of skin were removed from beige C57BL/6 (bgJ/bgJ. Chediak-Higashi syndrome) mice after various doses of irradiation and grafted onto the back of the normal C57BL/6 mice. Radiosensitivity of mast-cell precursors in the skin was evaluated by determining the decrease of beige-type mast cells which possessed giant granules. Mast-cell precursors in the bone marrow were much more radiosensitive than those localized in the skin. D0 value was about 100 rad for the former andmore » about 800 rad for the latter.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6185235
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiat. Res.; (United States); Journal Volume: 93:1
Research Org:
Institute for Cancer Research, Medical School, Osaka University, Kita-ku, Japan
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW CELLS; BIOLOGICAL RADIATION EFFECTS; RADIOSENSITIVITY; MAST CELLS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIPS; EXTRACORPOREAL IRRADIATION; INJECTION; MICE; RADIATION DOSES; SKIN; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CONNECTIVE TISSUE CELLS; DOSES; EXTERNAL IRRADIATION; INTAKE; IRRADIATION; MAMMALS; ORGANS; RADIATION EFFECTS; RODENTS; SOMATIC CELLS; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals; 560121 -- Radiation Effects on Cells-- External Source-- (-1987)