Clearance of [sup 99m]Tc-DTPA and experimentally increased alveolar surfactant content

Journal Article · Wed Apr 01 00:00:00 EST 1992 · Journal of Applied Physiology (1985); (United States)

OSTI ID:6176612

Bos, J A.H.; Wollmer, P; Bakker, W; Hannappel, E; Lachmann, B ^[1]

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1. Erasmus Univ., Rotterdam (Netherlands) Univ. of Lund (Sweden) Univ. of Erlangen (Germany)

The authors measured clearance of [sup 99m]Tc-labeled diethylenetriamine pentaacetic acid ([sup 99m]Tc-DTPA) in rabbits with experimentally increased alveolar surfactant content. In one group of animals, surfactant production was increased by treatment with ambroxol, and another group of animals was treated with tracheal instillation of natural surfactant. A group of untreated control animals and animals treated with instillation of saline were also studied. Clearance was measured during standard conditions of mechanical ventilation and during ventilation with large tidal volumes. In ambroxol- and surfactant-treated groups, clearance rate was reduced compared with untreated control animals. In contrast, clearance rate increased after saline instillation. The differences were observed at both modes of ventilation. The findings indicate that the pulmonary surfactant system is a rate-limiting factor for the clearance of [sup 99m]Tc-DTPA and that the volume dependence of clearance is not explained by stretching of the alveolar wall only. 28 refs., 2 figs., 1 tab.

• OSTI ID: 6176612
• Journal Information: Journal of Applied Physiology (1985); (United States), Vol. 72:4; ISSN 8750-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DTPA
LUNG CLEARANCE
SURFACTANTS
BIOLOGICAL EFFECTS
TECHNETIUM 99
RABBITS
RADIOPHARMACEUTICALS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOI
560160* - Radionuclide Effects
Kinetics
& Toxicology