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Title: Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy

Abstract

Cultured human lymphocytes were subjected to irradiation with a gallium-arsenide laser at energy fluence varying from 2.17 to 651 mJ/cm2, and the cell proliferation was assessed by (/sup 3/H)thymidine incorporation. Both mitogenic proliferation in response to phytohemagglutinin and spontaneous cell proliferation were markedly inhibited by the laser irradiation at energy fluence as low as 10.85 mJ/cm2. Similarly, the functional response of cells to antigen stimulation in a one-way mixed-lymphocyte reaction was also diminished as a result of laser irradiation. The results indicate that laser irradiation at low energy can interfere with immune system in vitro, and similar modulation could potentially occur in human subjects exposed to laser irradiation in vivo.

Authors:
; ;
Publication Date:
OSTI Identifier:
6174773
Resource Type:
Journal Article
Journal Name:
Lasers Surg. Med.; (United States)
Additional Journal Information:
Journal Volume: 7:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; LASER RADIATION; BIOLOGICAL EFFECTS; LYMPHOCYTES; CELL PROLIFERATION; RETICULOENDOTHELIAL SYSTEM; SENSITIVITY; ANTIGENS; DOSE-RESPONSE RELATIONSHIPS; IN VITRO; INHIBITION; LASERS; MAN; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; AZINES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; LEUKOCYTES; MAMMALS; MATERIALS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PRIMATES; PYRIMIDINES; RADIATIONS; RIBOSIDES; SOMATIC CELLS; TISSUES; VERTEBRATES; 560400* - Other Environmental Pollutant Effects; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Ohta, A, Abergel, R P, and Uitto, J. Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy. United States: N. p., 1987. Web. doi:10.1002/lsm.1900070211.
Ohta, A, Abergel, R P, & Uitto, J. Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy. United States. https://doi.org/10.1002/lsm.1900070211
Ohta, A, Abergel, R P, and Uitto, J. 1987. "Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy". United States. https://doi.org/10.1002/lsm.1900070211.
@article{osti_6174773,
title = {Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy},
author = {Ohta, A and Abergel, R P and Uitto, J},
abstractNote = {Cultured human lymphocytes were subjected to irradiation with a gallium-arsenide laser at energy fluence varying from 2.17 to 651 mJ/cm2, and the cell proliferation was assessed by (/sup 3/H)thymidine incorporation. Both mitogenic proliferation in response to phytohemagglutinin and spontaneous cell proliferation were markedly inhibited by the laser irradiation at energy fluence as low as 10.85 mJ/cm2. Similarly, the functional response of cells to antigen stimulation in a one-way mixed-lymphocyte reaction was also diminished as a result of laser irradiation. The results indicate that laser irradiation at low energy can interfere with immune system in vitro, and similar modulation could potentially occur in human subjects exposed to laser irradiation in vivo.},
doi = {10.1002/lsm.1900070211},
url = {https://www.osti.gov/biblio/6174773}, journal = {Lasers Surg. Med.; (United States)},
number = ,
volume = 7:2,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1987},
month = {Thu Jan 01 00:00:00 EST 1987}
}