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Title: Uptake of perfusion imaging agents by transplanted hearts: an experimental study in rats

There is a need for a reliable noninvasive marker of rejection in transplanted hearts. Endomyocardial biopsy is now the universally accepted diagnostic method of choice, but the invasiveness of the procedure and the limited size of the sample obtained makes this method far from ideal. As coronary blood flow may be expected to decrease during acute rejection, there has been interest in thallium-201 chloride (T1), a perfusion marker, as an imaging agent for diagnosing cardiac rejection. Hexakis(t-butylisonitrile)-technetium (Tc-TBI) is a representative of a new class of radiopharmaceuticals proposed as perfusion markers. We have compared the uptake of these imaging agents in a rat model of cardiac transplantation. Uptake of Tc-TBI as well as of T1 was significantly lower in rejecting than in nonrejecting hearts. This change was found in both left (LV) and right (RV) ventricles. Allografts in animals treated with cyclosporine (CyA) showed less severe rejection and higher uptakes of both imaging agents as compared to unmodified rejection. Our results suggest that perfusion imaging with these radionuclides is a potentially useful approach to the problem of detecting allograft rejection.
Authors:
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Publication Date:
OSTI Identifier:
6173472
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Surg. Res.; (United States); Journal Volume: 46:2
Research Org:
Buffalo Veterans Administration Medical Center, NY (USA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GRAFT-HOST REACTION; DIAGNOSIS; HEART; TRANSPLANTS; RADIOPHARMACEUTICALS; UPTAKE; BIOLOGICAL MARKERS; BIOLOGICAL MODELS; BLOOD FLOW; MYOCARDIUM; ORGANOMETALLIC COMPOUNDS; PERFUSED ORGANS; RATS; TECHNETIUM ISOTOPES; THALLIUM 201; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; VERTEBRATES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics