Hepatobiliary kinetics after whole-body irradiation
The purpose of this investigation was to study hepatobiliary kinetics after whole-body gamma irradiation. Two groups of nine male beagle dogs were irradiated with a single whole body dose of 4- and 8-Gy cobalt-60 photons. Each animal was injected with 2 mCi Tc-99m DISIDA and scintigraphic studies were obtained with a gamma camera with a parallel hole multipurpose collimator. The parameters studied included: peak activity of the liver and gall bladder and gall bladder and intestinal visualization from the time of Tc-99m DISIDA administration. Total and indirect bilirubin, LDH, SGOT, and SGPT determined as baseline studies before irradiation and at different time intervals after irradiation were not changed in irradiated animals. Whole body Co-60 irradiation with 4 and 8 Gy produced no significant changes in the Tc-99m DISIDA visualization of the gall bladder or in the peak activity in the gall bladder or the liver 1 and 7 days after irradiation. Intestinal visualization occurred significantly earlier in 8 Gy Co-60 irradiated animals on both day 1 and day 7 post irradiation, compared to baseline values where it was never observed before 195.0 minutes. Gall bladder emptying is significantly accelerated after 8 Gy but not after 4-Gy Co-60 gamma irradiation. These observations suggest that gamma irradiation stimulates gall bladder contractility without modifying intrahepatic biliary kinetics.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6169289
- Report Number(s):
- AD-A-181851/7/XAB; AFRRI-SR-86-38
- Resource Relation:
- Other Information: Pub. in Military Medicine, Vol. 151, No. 9, 487-489(Sep 1986)
- Country of Publication:
- United States
- Language:
- English
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DOGS
WHOLE-BODY IRRADIATION
LIVER
BIOLOGICAL RADIATION EFFECTS
BILE
CAMERAS
CONTRACTION
GAMMA RADIATION
KINETICS
MALES
PHOTON BEAMS
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GLANDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MATERIALS
ORGANS
RADIATION EFFECTS
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VERTEBRATES
560152* - Radiation Effects on Animals- Animals