Misonidazole with dexamethasone rescue: an escalating dose toxicity study
Neurotoxicity induced by misonidazole (MISO) and desmethylmisonidazole (DMM) has become the dose limiting factor in clinical work. In 1981, the authors reported a preliminary study suggestive that Dexamethasone (DEXA) does have a protective effect against peripheral neuropathies (PN) resulting from toxicity of misonidazole. The authors are presently investigating the use of DEXA, with escalating doses of MISO in an attempt to modify its neurotoxicity. To date, 16 patients have been registered to receive total doses of MISO given in 9 equally divided doses over 3 weeks. DEXA is given 3 days prior to the first dose and continues for the duration of therapy. All patients receive palliative radiation. No toxicity was seen at the total dose of 13.5 gm/M/sub 2/. One grade I PN occurred in the first four patients receiving 15.5 gm/M/sub 2/. Six additional patients were entered at this dose level and no further incidence of PN was observed.
- Research Organization:
- Cross Cancer Inst., Edmonton, Alberta
- OSTI ID:
- 6166515
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
DEXAMETHASONE
RADIOSENSITIVITY EFFECTS
MISONIDAZOLE
PHARMACOLOGY
TOXICITY
INFLAMMATION
METASTASES
NEOPLASMS
NERVES
PATIENTS
RADIOTHERAPY
ADRENAL HORMONES
ANTINEOPLASTIC DRUGS
AZOLES
CORTICOSTEROIDS
DISEASES
DRUGS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIDAZOLES
KETONES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PREGNANES
RADIOLOGY
RADIOSENSITIZERS
STEROID HORMONES
STEROIDS
SYMPTOMS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)