Using the integral spleen method of radiorenogram analysis and a baboon model to compare the diagnostic usefulness of technetium-99m-diethylenetriamine pentaacetic acid to that of various technetium-99m-mercaptoacetyltriglycene formulations and iodine-123-hippuran
In light of the high price of commercially available mercaptoacetyltriglycene (MAG3) it was decided to attempt a local MAG3-formation and to test this against diethylenetriamine pentaacetic acid (DTPA), /sup 123/I-Hippuran, and commercial MAG3 for diagnostic radiorenographic capabilities also in conjunction with furosemide and captopril. A baboon model (n = 6) was used, and the parameters evaluated were obtained by the integral spleen method of radiorenogram analysis. Although the images and parameters pointed to /sup 123/I-Hippuran and commercial MAG3 as the ideal renal scanning agents and to DTPA as the least so, with the local product an acceptable alternative, the differences were not significant enough to warrant either the purchase of the commercial product or the extensive development of the local product. Inexpensive /sup 99m/Tc-DTPA in conjunction with modern computer techniques will probably supply most of the answers.
- Research Organization:
- Univ. of Pretoria (South Africa)
- OSTI ID:
- 6152490
- Journal Information:
- Am. J. Physiol. Imaging; (United States), Vol. 4:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KIDNEYS
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
BIOLOGICAL MODELS
DTPA
IMAGE PROCESSING
IODINE 123
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
550601* - Medicine- Unsealed Radionuclides in Diagnostics