Photoreactivation and other ultraviolet/visible light effects on DNA in human skin

Conference · Sun Jan 01 00:00:00 EST 1984

OSTI ID:6152411

Sutherland, B M; Blackett, A D; Feng, N I; Freeman, S E; Ogut, E S; Gange, R W; Sutherland, J C

A computer-based system was devised for examining low levels (1 dimer/10/sup 8/ d) of DNA damage in human skin exposed to ultraviolet or visible radiation. The production of measurable levels of dimers was determined for light of wavelengths absorbed directly by DNA (290-320 nm). Exposure of skin to uv-A (320-380 nm) sources also produced significant numbers of endonuclease-sensitive sites. The immediate pigment darkening reaction (IPD) was tested to see whether IPD protects against uv-induced dimer formation. 29 references, 2 figures, 1 table. (ACR)

• Research Organization: Brookhaven National Lab., Upton, NY (USA); Harvard Medical School, Boston, MA (USA). Dept. of Dermatology
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6152411
• Report Number(s): BNL-35477; CONF-8410211-1; ON: DE85005135
• Resource Relation: Conference: New York Academy of Science conference on medical and biological effects of light, New York, NY, USA, 31 Oct 1984
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DNA
INJURIES
ENZYME ACTIVITY
PHOTOREACTIVATION
SKIN
BIOLOGICAL RADIATION EFFECTS
DIMERS
DNA REPAIR
MAN
MELANIN
RESPONSE MODIFYING FACTORS
ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
ELECTROMAGNETIC RADIATION
HYDROXY COMPOUNDS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
VERTEBRATES
560115* - Radiation Effects on Biochemicals- In Man- (-1987)