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Title: Effect of pretreatment with cysteamine on gamma-radiation-induced sister chromatid exchanges in mouse bone marrow cells in vivo

The effect of pretreatment with cysteamine on gamma-radiation-induced sister chromatid exchanges (SCEs) and on the mitotic index and average generation time was determined. Groups of mice were treated in one of the following regimens: (1) irradiated, (2) treated with cysteamine and irradiated, (3) treated with cysteamine only, or (4) left untreated. Intraperitoneal administration of cysteamine preceding gamma-radiation exposure protected against SCE induction. However, radioprotection was not reflected by change in the mitotic index or in the average generation time. The results suggest that, under the experimental conditions of this study, the SCEs are caused by free radicals produced by gamma radiation, but not the additional damage indices measured.
Authors:
;
Publication Date:
OSTI Identifier:
6149071
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiat. Res.; (United States); Journal Volume: 118:1
Research Org:
Instituto Nacional de Investigaciones Nucleares (Mexico)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MEA; RADIOSENSITIVITY EFFECTS; SISTER CHROMATID EXCHANGES; RADIOINDUCTION; BONE MARROW CELLS; COBALT ISOTOPES; GAMMA RADIATION; MICE; RADICALS; AMINES; ANIMAL CELLS; ANIMALS; CHROMOSOMAL ABERRATIONS; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; ISOTOPES; MAMMALS; MUTATIONS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RODENTS; SOMATIC CELLS; THIOLS; VERTEBRATES 560120* -- Radiation Effects on Biochemicals, Cells, & Tissue Culture