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Title: Aflatoxin B1 induced hepatic neoplasia in Great Lakes coho salmon

There is considerable interest in the development of fish models for carcinogen bioassays and the study of chemically induced cancer in wild fish species. Among salmonid species, rainbow trout have mainly been used for carcinogenesis research, in part due to the role played by this species in the discovery of the carcinogenic action of aflatoxin B1 (AFB1). Recently, apparatus and methodology for microinjection of salmonid fish embryos with chemical carcinogens has been described. Because eggs produced by Pacific salmon are relatively much larger than those of rainbow trout, they would provide an attractive subject for embryo microinjection. The Great Lakes are annually stocked with large numbers of coho salmon. It has been recommended to use coho salmon as an indicator for monitoring ecosystem health in the Great Lakes, because stockings throughout health in the Great Lakes, because stockings throughout the Great Lakes are from a common genetic strain and in the lake environment they have a defined food source and life cycle. These considerations led the authors to test coho salmon for their sensitivity to the potent hepatocarcinogen, AFB1. The present report describes in preliminary form, the results of these experiments.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6143118
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bull. Environ. Contam. Toxicol.; (United States); Journal Volume: 41:5
Research Org:
Roswell Park Memorial Institute, Buffalo, NY (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AFLATOXIN; BIOLOGICAL EFFECTS; NEOPLASMS; HISTOLOGY; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIPS; EGGS; GREAT LAKES; LIVER; MORTALITY; SALMON; ANADROMOUS FISHES; ANIMALS; ANTIGENS; AQUATIC ORGANISMS; BODY; DIGESTIVE SYSTEM; DISEASES; FISHES; GLANDS; LAKES; MATERIALS; ORGANS; SURFACE WATERS; TOXIC MATERIALS; TOXINS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology