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Title: Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children

Abstract

The effect of hepatic irradiation on adriamycin toxicity and pharmacokinetics was studied in 10 children who received adriamycin with concurrent abdominal irradiation for Wilms' tumor. Hepatic irradiation to 2400 to 2700 rad at 100 to 150 rad per fraction did not alter the clinical toxicity or plasma pharmacokinetics of adriamycin.

Authors:
 [1]; ; ;
  1. Medical Coll. of Wisconsin, Milwaukee
Publication Date:
OSTI Identifier:
6141892
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 7:7
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; DOXORUBICIN; PHARMACOLOGY; RADIOSENSITIVITY EFFECTS; LEUKOPENIA; RADIOINDUCTION; NAUSEA; RADIOTHERAPY; SIDE EFFECTS; VOMITING; CHILDREN; FRACTIONATED IRRADIATION; LIVER; NEOPLASMS; SURGERY; AGE GROUPS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTINEOPLASTIC DRUGS; BODY; DIGESTIVE SYSTEM; DISEASES; DRUGS; GLANDS; HEMIC DISEASES; IRRADIATION; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Holcenberg, J S, Kun, L E, Ring, B J, and Evans, W E. Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children. United States: N. p., 1981. Web. doi:10.1016/0360-3016(81)90015-8.
Holcenberg, J S, Kun, L E, Ring, B J, & Evans, W E. Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children. United States. https://doi.org/10.1016/0360-3016(81)90015-8
Holcenberg, J S, Kun, L E, Ring, B J, and Evans, W E. 1981. "Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children". United States. https://doi.org/10.1016/0360-3016(81)90015-8.
@article{osti_6141892,
title = {Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children},
author = {Holcenberg, J S and Kun, L E and Ring, B J and Evans, W E},
abstractNote = {The effect of hepatic irradiation on adriamycin toxicity and pharmacokinetics was studied in 10 children who received adriamycin with concurrent abdominal irradiation for Wilms' tumor. Hepatic irradiation to 2400 to 2700 rad at 100 to 150 rad per fraction did not alter the clinical toxicity or plasma pharmacokinetics of adriamycin.},
doi = {10.1016/0360-3016(81)90015-8},
url = {https://www.osti.gov/biblio/6141892}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 7:7,
place = {United States},
year = {Wed Jul 01 00:00:00 EDT 1981},
month = {Wed Jul 01 00:00:00 EDT 1981}
}