Intraocular radiation blocking

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Investigative Ophthalmology and Visual Science; (USA)

OSTI ID:6141673

Finger, P T; Ho, T K; Fastenberg, D M; Hyman, R A; Stroh, E M; Packer, S; Perry, H D ^[1]

---

1. North Shore Univ. Hospital, Manhasset, NY (USA)

Iodine-based liquid radiographic contrast agents were placed in normal and tumor-bearing (Greene strain) rabbit eyes to evaluate their ability to block iodine-125 radiation. This experiment required the procedures of tumor implantation, vitrectomy, air-fluid exchange, and 125I plaque and thermoluminescent dosimetry (TLD) chip implantation. The authors quantified the amount of radiation attenuation provided by intraocularly placed contrast agents with in vivo dosimetry. After intraocular insertion of a blocking agent or sham blocker (saline) insertion, episcleral 125I plaques were placed across the eye from episcleral TLD dosimeters. This showed that radiation attenuation occurred after blocker insertion compared with the saline controls. Then computed tomographic imaging techniques were used to describe the relatively rapid transit time of the aqueous-based iohexol compared with the slow transit time of the oil-like iophendylate. Lastly, seven nontumor-bearing eyes were primarily examined for blocking agent-related ocular toxicity. Although it was noted that iophendylate induced intraocular inflammation and retinal degeneration, all iohexol-treated eyes were similar to the control eyes at 7 and 31 days of follow-up. Although our study suggests that intraocular radiopaque materials can be used to shield normal ocular structures during 125I plaque irradiation, a mechanism to keep these materials from exiting the eye must be devised before clinical application.

• OSTI ID: 6141673
• Journal Information: Investigative Ophthalmology and Visual Science; (USA), Vol. 31:9; ISSN 0146-0404
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CONTRAST MEDIA
RADIOSENSITIVITY EFFECTS
EYES
EXPERIMENTAL NEOPLASMS
COMPUTERIZED TOMOGRAPHY
IODINE 125
RABBITS
THERMOLUMINESCENT DOSIMETRY
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SENSE ORGANS
TOMOGRAPHY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)