Effects of coadministered sodium selenite on short-term distribution on methyl mercury in the rat
Adult male Sprague-Dawley rats received iv injections of 1 ..mu..mole of methyl mercury/kg alone or coadministered with 5 ..mu..mole of sodium selenite/kg. Tissue concentrations of methyl mercury were determined at 5, 20, and 60 min after treatment. Selenite treatment produced a significant increase in cerebral methyl mercury concentrations and a significant decrease in kidney methyl mercury concentrations at all time points. The concentration of methyl mercury in liver was significantly increased by selenite coadministration at 5 and 20 min but at 60 min after injection the concentration was not significantly different from that found in rats receiving methyl mercury alone. Selenite treatment also significantly lowered blood methyl mercury concentrations at all time points. This decrease was associated with a significant decrease in the concentration of methyl mercury in erythrocytes at 5, 20, and 60 min. Plasma methyl mercury levels at 5 min postinjection were slightly higher in selenite-treated rats but were significantly lower in treated animals at 20 and 60 min. Treatment of rats with selenite did not specifically alter the extent of methyl mercury binding to glutathione in the 108,000 g supernatant of cerebrum of in erythrocyte hemolysates. In rats receiving either methyl mercury alone or with selenite, low-molecular-weight methyl mercury complexes could not be detected in plasma 5 min after iv injection.
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, NY
- OSTI ID:
- 6133953
- Journal Information:
- Environ. Res.; (United States), Vol. 34:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
METHYLMERCURY
BIOLOGICAL LOCALIZATION
TISSUE DISTRIBUTION
SELENIUM COMPOUNDS
BIOLOGICAL EFFECTS
BLOOD PLASMA
CEREBRUM
CHEMICAL ANALYSIS
ERYTHROCYTES
EXPERIMENTAL DATA
GLUTATHIONE
KIDNEYS
LIVER
RATS
SODIUM COMPOUNDS
TIME DEPENDENCE
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
GLANDS
INFORMATION
MAMMALS
MATERIALS
MERCURY COMPOUNDS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)