Influence of dietary selenium on mouse lung biochemical response and tolerance to ozone inhalation

Thesis/Dissertation · Sat Jan 01 00:00:00 EST 1983

OSTI ID:6133545

Elsayed, N M

This study examined whether altered selenium (Se) intake with or without ozone (O/sub 3/) stress would result in a possible 1) dose-response relationship between lung Se and glutathione peroxidase, 2) influence of Se on other lung parameters, 3) interrelationship between lung Se and vitamin E contents, and 4) alteration of lung sensitivity or tolerance to O/sub 3/. The results showed the following: 1) Omission of dietary Se resulted in a drastic decline in GP activity but did not affect the other enzyme activities studied. 2) A stimulation of the PPC and CAC activites with low-level O/sub 3/ exposure occurred only in Se-supplemented mice. The stimulation was greater in the lungs of mice fed 1.0 ppm Se compared to 0.15 ppm, i.e., the response was Se-dose dependent in this range. 3) Diminished GP activity possibly resulted in a decreased demand for NADPH produced via not only the PPC but also the CAC. 4) An inverse relationship was observed between Se and vitamin E contents in lung tissue, showing that a compensatory relationship existed between the two. 5) After each O/sub 3/ exposure Se content increased in lung tissue of both dietary groups, suggesting a possible mobilization of Se to the lung under O/sub 3/ stress. 6) Decreased GP activity due to Se deficiency and the ensuring lack of stimulated NADPH production in the lung did not alter the animal sensitivity to O/sub 3/, suggesting that GP reaction and NADPH production cycles were not crucial for animal tolerance.

• OSTI ID: 6133545
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
BIOLOGICAL EFFECTS
RESPONSE MODIFYING FACTORS
SELENIUM
BIOCHEMISTRY
DOSE-RESPONSE RELATIONSHIPS
INGESTION
LUNGS
MICE
PEROXIDASES
TOLERANCE
VITAMIN E
ANIMALS
BODY
CARBOXYLIC ACIDS
CHEMISTRY
ELEMENTS
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTAKE
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PORPHYRINS
RESPIRATORY SYSTEM
RODENTS
SEMIMETALS
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)