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Title: Inborn anemias in mice

hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, five hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an ..cap alpha..-thalassemia, and a new target-cell anemia. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse. Each anemia is studied through: (a) characterization of peripheral blood values, (b) determinations of radiosensitivity under a variety of conditions, (c) measurements of iron metabolism and heme synthesis, (d) histological and biochemical study of blood-forming tissue, (e) functional tests of the stem cell component, (f) examination of responses to erythroid stimuli, and (g) transplantation of tissue between individuals of differently affected genotypes.
Authors:
; ;
Publication Date:
OSTI Identifier:
6121812
Report Number(s):
DOE/EV/03264-20
ON: DE81029128; TRN: 81-015456
DOE Contract Number:
AS02-76EV03264
Resource Type:
Technical Report
Research Org:
Jackson Lab., Bar Harbor, ME (USA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANEMIAS; RESEARCH PROGRAMS; BLOOD CHEMISTRY; BLOOD FORMATION; HOMEOSTASIS; IRON; METABOLISM; MICE; RADIOSENSITIVITY; TRANSPLANTS; ANIMALS; DISEASES; ELEMENTS; HEMIC DISEASES; MAMMALS; METALS; RODENTS; SYMPTOMS; TRANSITION ELEMENTS; VERTEBRATES 550900* -- Pathology; 560152 -- Radiation Effects on Animals-- Animals