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Title: Distribution of /sup 3/H-morphine following lumbar subarachnoid injection in unanesthetized rabbits

Abstract

Morphine sulfate (40-100 micrograms) and /sup 3/H-morphine (125-200 pmol) were injected into the lumbar subarachnoid space of 18 unanesthetized rabbits through a surgically implanted catheter. Radioactivity remaining in the spinal cord 2, 4, 6, and 12 h later revealed recovery (mean +/- SEM) of 45 +/- 5.6% (n = 3), 30.5 +/- 14.1% (n = 4), 11.23 +/- 4.4% (n = 3), and 3.7 +/- 1.1% (n = 3), respectively, of the injected radioactivity. Tritiated morphine was found to be predominantly centered around the injection site, with limited rostral and caudal spread in the cord. No significant radioactivity was detected in plasma or cerebrospinal fluid (CSF) samples from the cisterna magna taken at 5, 15, 30, min and 1, 2, 4, 6, 12, and 24 h after receiving radioactive labeled drug (with the exception of that in one rabbit). Of the injected radioactivity, 75% was recovered in the urine in 12 h. These results suggest that the persistence of morphine in the spinal cord could account for its prolonged analgesic effect following intrathecal administration.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
New York Univ. School of Medicine, NY (USA)
OSTI Identifier:
6080691
Resource Type:
Journal Article
Journal Name:
Anesthesiology; (United States)
Additional Journal Information:
Journal Volume: 70:5
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; MORPHINE; TISSUE DISTRIBUTION; CEREBROSPINAL FLUID; RABBITS; SPINAL CORD; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ALKALOIDS; ANALGESICS; ANIMALS; BIOLOGICAL MATERIALS; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISTRIBUTION; DRUGS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NARCOTICS; NERVOUS SYSTEM; OPIUM; ORGANIC COMPOUNDS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Wang, B C, Hiller, J M, Simon, E J, Hillman, D E, Rosenberg, C, and Turndorf, H. Distribution of /sup 3/H-morphine following lumbar subarachnoid injection in unanesthetized rabbits. United States: N. p., 1989. Web. doi:10.1097/00000542-198905000-00019.
Wang, B C, Hiller, J M, Simon, E J, Hillman, D E, Rosenberg, C, & Turndorf, H. Distribution of /sup 3/H-morphine following lumbar subarachnoid injection in unanesthetized rabbits. United States. https://doi.org/10.1097/00000542-198905000-00019
Wang, B C, Hiller, J M, Simon, E J, Hillman, D E, Rosenberg, C, and Turndorf, H. 1989. "Distribution of /sup 3/H-morphine following lumbar subarachnoid injection in unanesthetized rabbits". United States. https://doi.org/10.1097/00000542-198905000-00019.
@article{osti_6080691,
title = {Distribution of /sup 3/H-morphine following lumbar subarachnoid injection in unanesthetized rabbits},
author = {Wang, B C and Hiller, J M and Simon, E J and Hillman, D E and Rosenberg, C and Turndorf, H},
abstractNote = {Morphine sulfate (40-100 micrograms) and /sup 3/H-morphine (125-200 pmol) were injected into the lumbar subarachnoid space of 18 unanesthetized rabbits through a surgically implanted catheter. Radioactivity remaining in the spinal cord 2, 4, 6, and 12 h later revealed recovery (mean +/- SEM) of 45 +/- 5.6% (n = 3), 30.5 +/- 14.1% (n = 4), 11.23 +/- 4.4% (n = 3), and 3.7 +/- 1.1% (n = 3), respectively, of the injected radioactivity. Tritiated morphine was found to be predominantly centered around the injection site, with limited rostral and caudal spread in the cord. No significant radioactivity was detected in plasma or cerebrospinal fluid (CSF) samples from the cisterna magna taken at 5, 15, 30, min and 1, 2, 4, 6, 12, and 24 h after receiving radioactive labeled drug (with the exception of that in one rabbit). Of the injected radioactivity, 75% was recovered in the urine in 12 h. These results suggest that the persistence of morphine in the spinal cord could account for its prolonged analgesic effect following intrathecal administration.},
doi = {10.1097/00000542-198905000-00019},
url = {https://www.osti.gov/biblio/6080691}, journal = {Anesthesiology; (United States)},
number = ,
volume = 70:5,
place = {United States},
year = {Mon May 01 00:00:00 EDT 1989},
month = {Mon May 01 00:00:00 EDT 1989}
}