Development of alpha-emitting radionuclide lead 212 for the potential treatment of ovarian carcinoma

Journal Article · Sat Apr 01 00:00:00 EST 1989 · Am. J. Obstet. Gynecol.; (United States)

DOI:https://doi.org/10.1016/0002-9378(89)90293-7· OSTI ID:6075811

Rotmensch, J; Atcher, R W; Hines, J; Grdina, D; Schwartz, J S; Toohill, M; Herbst, A L

alpha-Emitting radionuclides may be an effective alternative treatment against ovarian carcinoma because they have short half-lives and are densely ionizing, with high linear energy transfer to a depth of several cell diameters without requiring cellular oxygenation. One radionuclide that has been generated and tested in our laboratory in vitro and in vivo is lead 212 (/sup 212/Pb). Intraperitoneal instillation of /sup 212/Pb prolonged survival and totally eradicated tumor in 24% of mice inoculated with the extremely virulent Ehrlich ascites-producing tumor. In vitro /sup 212/Pb was two to four times more effective in killing human ovarian cancer cells than x-rays. Irradiation with /sup 212/Pb increased the radiosensitivity and chromosomal aberrations of cells. In dogs, intraperitoneal instillation of 2.6 mCi of ferrous hydroxide tagged with /sup 212/Pb caused no significant toxicity. It appears that alpha-emitting radionucides such as /sup 212/Pb have the potential to be a new and potent treatment of ovarian carcinoma and could be effective in cases that are resistant to conventional chemotherapy or x-ray therapy.

• Research Organization: Univ. of Chicago Pritzker School of Medicine, IL (USA)
• OSTI ID: 6075811
• Journal Information: Am. J. Obstet. Gynecol.; (United States), Vol. 160:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
EHRLICH ASCITES TUMOR
RADIOSENSITIVITY
OVARIES
BIOLOGICAL HALF-LIFE
INTRAPERITONEAL INJECTION
LEAD 212
LET
MICE
SURVIVAL CURVES
TOXICITY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DISEASES
ENERGY TRANSFER
EVEN-EVEN NUCLEI
EXPERIMENTAL NEOPLASMS
FEMALE GENITALS
GONADS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
ISOTOPES
LEAD ISOTOPES
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)