Regional cerebral incorporation of plasma (/sup 14/C)palmitate, and cerebral glucose utilization, in water-deprived Long-Evans and Brattleboro rats

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Exp. Neurol.; (United States)

DOI:https://doi.org/10.1016/0014-4886(89)90050-2· OSTI ID:6075640

Noronha, J G; Larson, D M; Rapoport, S I

Regional rates of incorporation into brain of intravenously administered (/sup 14/C)palmitate and regional cerebral metabolic rates for glucose (rCMRglc) were measured in water-provided (WP) and water-deprived (WD) homozygous (DI) and heterozygous (HZ) Brattleboro rats, a mutant strain unable to synthesize vasopressin, and in the parent Long-Evans (LE) strain. Following 15 h or 4 days of water deprivation, rCMRglc was elevated threefold in the pituitary neural lobe of LE-WD and DI-WD as compared with LE-WP rats, and in the paraventricular nucleus of LE-WD, and the supraoptic nucleus of DI-WD rats. However, incorporation of (/sup 14/C)palmitate into these regions was not specifically altered. The results indicate that water deprivation for up to 4 days increases rCMRglc in some brain regions involved with vasopressin, but does not alter (/sup 14/C)palmitate incorporation into these regions. Incorporation of plasma (/sup 14/C)palmitate is independent of unlabeled plasma palmitate at brain regions which have an intact blood-brain barrier, but at nonbarrier regions falls according to saturation kinetics as cold plasma concentration rises, with a mean half-saturation constant (Km) equal to 0.136 mumol.ml-1.

• Research Organization: National Institute on Aging, Bethesda, MD (USA)
• OSTI ID: 6075640
• Journal Information: Exp. Neurol.; (United States), Vol. 103:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
METABOLISM
HEXADECANOIC ACID
UPTAKE
BLOOD-BRAIN BARRIER
BRAIN
CARBON 14 COMPOUNDS
RATS
TRACER TECHNIQUES
VASOPRESSIN
WATER
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
RODENTS
SACCHARIDES
VERTEBRATES
550501* - Metabolism- Tracer Techniques