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Title: Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin

Abstract

Three analogues of the tridecapeptide amide H-Leu-(Glu)5-Ala-Tyr-Gly-Nle-Asp-Phe-NH2 were synthetized with alpha-deuterated glutamate residues in specific positions in order to assign unambiguously the 1H NMR spectrum of the parent peptide in water and in water-trifluoroethanol mixtures. The synthetic route is described and the assignment illustrated. A previous, tentative assignment based solely on indirect evidence was partially modified.

Authors:
; ; ; ;  [1]
  1. Univ. of Padua (Italy)
Publication Date:
OSTI Identifier:
6062621
Resource Type:
Journal Article
Journal Name:
Biopolymers; (USA)
Additional Journal Information:
Journal Volume: 30:7-8; Journal ID: ISSN 0006-3525
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GASTRIN; MOLECULAR STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL PREPARATION; DEUTERIUM; GLUTAMIC ACID; NMR SPECTRA; NUCLEAR MAGNETIC RESONANCE; PEPTIDES; PROTONS; TRACER TECHNIQUES; AMINO ACIDS; BARYONS; CARBOXYLIC ACIDS; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HORMONES; HYDROGEN ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; NUCLEI; NUCLEONS; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PEPTIDE HORMONES; POLYPEPTIDES; PROTEINS; RESONANCE; SPECTRA; STABLE ISOTOPES; SYNTHESIS; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Amonraksa, K, Simonetti, M, Da Rin-Fioretto, S, Mammi, S, and Peggion, E. Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin. United States: N. p., 1990. Web. doi:10.1002/bip.360300719.
Amonraksa, K, Simonetti, M, Da Rin-Fioretto, S, Mammi, S, & Peggion, E. Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin. United States. https://doi.org/10.1002/bip.360300719
Amonraksa, K, Simonetti, M, Da Rin-Fioretto, S, Mammi, S, and Peggion, E. 1990. "Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin". United States. https://doi.org/10.1002/bip.360300719.
@article{osti_6062621,
title = {Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin},
author = {Amonraksa, K and Simonetti, M and Da Rin-Fioretto, S and Mammi, S and Peggion, E},
abstractNote = {Three analogues of the tridecapeptide amide H-Leu-(Glu)5-Ala-Tyr-Gly-Nle-Asp-Phe-NH2 were synthetized with alpha-deuterated glutamate residues in specific positions in order to assign unambiguously the 1H NMR spectrum of the parent peptide in water and in water-trifluoroethanol mixtures. The synthetic route is described and the assignment illustrated. A previous, tentative assignment based solely on indirect evidence was partially modified.},
doi = {10.1002/bip.360300719},
url = {https://www.osti.gov/biblio/6062621}, journal = {Biopolymers; (USA)},
issn = {0006-3525},
number = ,
volume = 30:7-8,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}