Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:6059074

Huysmans, D A; Corstens, F H; Kloppenborg, P W ^[1]

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1. University Hospital Nijmegen (Netherlands)

The long-term effects of radioiodine treatment on thyroid function in patients with a toxic solitary autonomous thyroid nodule were evaluated. Fifty-two patients received a therapeutic dose of 20 mCi of iodine-131 ({sup 131}I). Duration of follow-up was 10 +/- 4 yr. Follow-up data included a biochemical evaluation of thyroid function. The failure rate (recurrent hyperthyroidism) was 2%. The incidence of hypothyroidism was 6% and was not related to the dose per gram of nodular tissue. Oral administration of 20 mCi of radioiodine is a simple and highly effective method for the treatment of patients with a toxic autonomous thyroid nodule. The risk of development of hypothyroidism is low if extranodular uptake of {sup 131}I is prevented. This can be achieved by not treating euthyroid patients, by no longer using injections of exogenous thyroid stimulating hormone in the diagnostic work-up of the patients and by always performing radioiodine imaging shortly before treatment.

• OSTI ID: 6059074
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:1; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
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HYPOTHYROIDISM
RADIOINDUCTION
NEOPLASMS
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THYROID
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ENDOCRINE GLANDS
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INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
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