Interactions of manganese, iron, and copper in healthy human subjects
In study I, plasma levels of manganese and iron were measured after an oral load was ingested. Four hourly samples of plasma were collected postdose. The ingestion of a dose of 40 mg Mn alone produced a typical response in plasma manganese, which peaked at either the first or second hour postdose. When a combined dose of 40 mg inorganic Fe plus 40 mg Mn was given, the plasma uptake of manganese was substantially inhibited when compared to a dose of 40 mg Mn alone. When the same quantity of heme Fe was substituted for the inorganic Fe in the load of inorganic Fe plus Mn, no depression in plasma manganese was observed. In study II, eight healthy female subjects were fed a baseline Mn-adequate diet of conventional foods for 18 days, followed by a Mn-deficient semi-purified diet for 41 days. Dietary levels of iron and copper averaged 17.7 mg and 4.3 mg/day, respectively, for both diets. Mean iron balance increased significantly from initial levels of 2.20 {plus minus} 1.07 mg/d to 5.02 {plus minus} 1.14 mg/d at the end of the Mn-deficient period. Parameters of iron status were not influenced by the variations of dietary manganese. In contrast, mean copper balance decreased from 2.61 {plus minus} 0.1 mg/d to 0.91 {plus minus} 0.4 mg/d at the end of the Mn-deficient period. Correspondingly, plasma copper and serum ceruloplasmin decreased from 18.57 {plus minus} 1.1 {mu}mol/L to 15.27 {plus minus} 0.94 {mu}mol/L and 269.1 {plus minus} 14.6 mg/L to 205.6 {plus minus} 17.8 mg/L., respectively.
- Research Organization:
- Texas Univ., Austin, TX (USA)
- OSTI ID:
- 6054827
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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