Effects of dietary calcium on lead absorption, distribution, and elimination kinetics in rats

Journal Article · Tue Jan 01 00:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530726· OSTI ID:6044672

Aungst, B J; Fung, H L

A pharmacokinetic analysis of lead absorption, distribution, and elimination was conducted in rats maintained on calcium-deficient, control, and calcium-supplemented diets. Dietary calcium affected lead disposition in a number of ways. Systematic lead clearance after a 10-mg/kg intracardiac lead dose was approximately 25% lower than control in rats administered dietary calcium supplements. In rats maintained on a calcium-deficient diet, systemic lead clearance was estimated to be 40% less than control. The apparent volume of lead distribution was increased. The apparent systemic availability of 1-, 10-, and 100-mg.kg oral lead doses was three- to fourfold greater than control in calcium-deficient rats. The percentage absorption was dose-dependent in control and calcium-deficient rats. The observed changes in lead absorption and systemic clearance associated with the calcium-deficient diet represent synergistic effects that could elevate blood lead accumulation and thus potentially influence susceptibility to lead toxicity.

• Research Organization: State Univ. of New York, Buffalo
• OSTI ID: 6044672
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 16:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CALCIUM
RESPONSE MODIFYING FACTORS
LEAD
BIOLOGICAL AVAILABILITY
METABOLISM
BIOLOGICAL ACCUMULATION
CLEARANCE
DOSE-RESPONSE RELATIONSHIPS
INTESTINAL ABSORPTION
NUTRITIONAL DEFICIENCY
RATS
TISSUE DISTRIBUTION
ABSORPTION
ALKALINE EARTH METALS
ANIMALS
DISTRIBUTION
ELEMENTS
MAMMALS
METALS
RODENTS
UPTAKE
VERTEBRATES
550500* - Metabolism
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)