Single high dose intraoperative electrons for advanced stage pancreatic cancer: Phase I pilot study
Phase I toxicity studies with intraoperative radiotherapy proved to be a feasible adjunct to surgery for unresectable malignancies of the pancreas at Howard University Hospital. There have been minimal side effects or complications related to the combination of limited surgical decompression and intraoperative radiotherapy alone. The toxic effects of intraoperative radiotherapy on normal tissues is being assessed on a dose volume basis. Doses of 2000 to 2500 rad in a single exposure to include the pancreas, regional nodes and duodenum are acceptable if the total treatment volume is less than or equal to 100 cm. The tumoricidal effects on the cancer are demonstratable when one reviews the pathological specimens that illustrate massive tumor necrosis and fibros replacement, but in all cases reviewed, viable cancer was noted. Intraoperative radiotherapy, therefore, represents a significant boost dose for resectable, partially resectable or non-resectable tumors when added to conventional external beam irradiation and/or chemotherapy. Preliminary clinical data and minimal toxicity justifies further investigation.
- Research Organization:
- Howard Univ. Hospital, Washington, DC
- OSTI ID:
- 6042148
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:7
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANOREXIA
RADIOINDUCTION
NAUSEA
NECROSIS
RADIOTHERAPY
SIDE EFFECTS
ULCERS
VOMITING
ELECTRONS
LARGE INTESTINE
LYMPH NODES
MEV RANGE 01-10
MEV RANGE 10-100
PANCREAS
PATIENTS
SURGERY
BODY
DIGESTIVE SYSTEM
ELEMENTARY PARTICLES
ENDOCRINE GLANDS
ENERGY RANGE
FERMIONS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
LEPTONS
LYMPHATIC SYSTEM
MEDICINE
MEV RANGE
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIOLOGY
SYMPTOMS
THERAPY
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