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Title: Adjuvant chemo- and hormonal therapy in locally advanced breast cancer: a randomized clinical study

Between 1977 and 1980, 118 breast cancer patients with locally advanced disease, T3B-4, any N, M0 or T1-3, tumor positive axillary apex biopsy, were randomized to one of three arms: I: radiotherapy (RT) to the breast and adjacent lymph node areas; II: RT followed by 12 cycles of cyclophosphamide, methotrexate, 5 fluorouracil (CMF) and tamoxifen during the chemotherapy period; III: 2 cycles of adriamycin and vincristine (AV), alternated with 2 cycles of CMF, then RT, followed by another 4 cycles of AV, alternated with 4 CMF; tamoxifen during the entire treatment period. The median follow-up period was 5 1/2 years. The adjuvant chemo- and hormonal therapy did not improve the overall survival; the 5-year survival was 37% for all three treatment arms. There was no statistically significant difference in RFS between the three modalities, nor when arm I was compared to arm II and III together. LR was not statistically different over the three treatment arms. In 18 of the 24 patients with LR, distant metastases appeared within a few months from the local recurrence. The menopausal status did not influence the treatment results. Dose reduction in more than 4 cycles of chemotherapy was accompanied by better results. In conclusion:more » adjuvant chemo- and hormonal therapy did not improve RFS and overall survival. These findings do not support the routine use of adjuvant chemo- and endocrine therapy for inoperable breast cancer.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6041661
Resource Type:
Journal Article
Resource Relation:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States); Journal Volume: 10
Research Org:
Netherlands Cancer Institute, Amsterdam
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; EVALUATION; RADIOTHERAPY; DOXORUBICIN; ENDOXAN; FLUOROURACILS; LYMPH NODES; MAMMARY GLANDS; MENOPAUSE; METHOTREXATE; ONCOVIN; PATIENTS; ALKALOIDS; ALKYLATING AGENTS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; AZINES; BODY; DRUGS; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMMUNOSUPPRESSIVE DRUGS; LYMPHATIC SYSTEM; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIOLOGY; THERAPY; URACILS 550603* -- Medicine-- External Radiation in Therapy-- (1980-)