New type of genome instability in Drosophila melanogaster

Journal Article · Tue Nov 01 00:00:00 EST 1988 · Sov. Genet. (Engl. Transl.); (United States)

OSTI ID:6036604

Georgiev, P G; Simonova, O B; Gerasimova, T I

During crossing of two stable laboratory lines, y/sup 2/sc/sup 1w/sup aG// and Df(1)Pgd-kz/FM4, y/sup 31d/sc/sup 8/dm B, consistent instability originated reproducibly in progeny containing a y/sup 2/sc/sup 1/w/sup aG/ chromosome and autosomes of both lines. It is expressed in active mutagenesis observed over the course of several tens of generations. Destabilization occurs independently of direction of crossing. Mutagenesis occurs both in somatic and in sex cells of males and females. It displays high locus specificity. A transpositional nature was shown for at least some of the mutations. Results of the experiments concerning hybridization in situ with different mobile elements indicates an absence or low frequency of tranpositional bursts in the system. Possible mechanisms of induction of genetic instability in the system described are discussed.

• Research Organization: N.I. Vavilov Institute of General Genetics, Moscow (USSR)
• OSTI ID: 6036604
• Journal Information: Sov. Genet. (Engl. Transl.); (United States), Vol. 24:5; Other Information: Translated from Genetika; 24: No. 5, 867-877(May 1988)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENOME MUTATIONS
INSTABILITY
SOMATIC CELLS
MUTAGENESIS
CROSSING-OVER
DNA SEQUENCING
DOMINANT MUTATIONS
DROSOPHILA
FEMALES
GENETIC MAPPING
GENOTYPE
HYBRIDIZATION
MALES
MOBILITY
MOSAICISM
MUTATION FREQUENCY
PROGENY
RADIOASSAY
RECESSIVE MUTATIONS
RECOMBINANT DNA
REVERTANTS
TRITIUM COMPOUNDS
X CHROMOSOME
Y CHROMOSOME
ANIMAL CELLS
ANIMALS
ARTHROPODS
CHROMOSOMES
DIPTERA
DNA
FLIES
FRUIT FLIES
HETEROCHROMOSOMES
INSECTS
INVERTEBRATES
LABELLED COMPOUNDS
MAPPING
MUTANTS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
STRUCTURAL CHEMICAL ANALYSIS
550401* - Genetics- Tracer Techniques
550301 - Cytology- Tracer Techniques