Modulation of ethanol-intake by morphine: Evidence for a central site of action

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90221-C· OSTI ID:6034747

Wild, K D; Reid, L D ^[1]

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1. Rensselaer Polytechnic Institute, Troy, NY (USA)

Previous studies have shown that subcutaneous administration of low doses of morphine increase, while subcutaneous naloxone decreases, ethanol-intake in rats. However, the site of action of morphine modulation of ethanol-intake remains unclear. In an attempt to elucidate this issue, seven graded doses of morphine were given intracerebroventricularly to rats 15 min prior to an opportunity to consume water and sweetened alcoholic beverage for 2 hr. Two lower doses of intracerebroventricular morphine reliably increased ethanol-intake, while higher doses decreased intake of water. Preference ratios were reliably increased by morphine doses of 1 {mu}g and higher. The present data provide support for a central site of morphine modulation of ethanol-intake.

• OSTI ID: 6034747
• Journal Information: Life Sciences; (USA), Vol. 47:14; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
INTAKE
MORPHINE
BIOLOGICAL EFFECTS
METABOLISM
RATS
ALCOHOLS
ALKALOIDS
ANALGESICS
ANIMALS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HYDROXY COMPOUNDS
MAMMALS
NARCOTICS
OPIUM
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology