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Title: Dehydroepiandrosterone inhibits the spontaneous release of superoxide radical by alveolar macrophages in vitro in asbestosis

Asbestosis is characterized by an alveolar macrophage alveolitis with injury and fibrosis of the lower respiratory tract. Alveolar macrophages recovered by bronchoalveolar lavage spontaneously release exaggerated amounts of oxidants including superoxide anion and hydrogen peroxide that may mediate alveolar epithelial cell injury. Dehydroepiandrosterone (DHEA) is a normally occurring adrenal androgen that inhibits glucose-6-phosphate dehydrogenase, the initial enzyme in the pentose phosphate shunt necessary for NADPH generation and superoxide anion formation. In this regard, the authors hypothesized that DHEA may reduce asbestos-induced oxidant release. DHEA added in vitro to alveolar macrophages lavaged from 11 nonsmoking asbestos workers significantly reduced superoxide anion release. DHEA is an antioxidant and potential anticarcinogenic agent that may have a therapeutic role in reducing the increased oxidant burden in asbestos-induced alveolitis of the lower respiratory tract.
Authors:
;  [1]
  1. (New York Univ. Medical Center, New York (United States))
Publication Date:
OSTI Identifier:
6024379
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; (United States); Journal Volume: 55:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANTIOXIDANTS; BIOLOGICAL EFFECTS; ASBESTOS; HEALTH HAZARDS; IN VITRO; LAVAGE; LUNGS; MACROPHAGES; OCCUPATIONAL EXPOSURE; SUPEROXIDE RADICALS; ANIMAL CELLS; BODY; CONNECTIVE TISSUE CELLS; HAZARDS; ORGANS; PHAGOCYTES; RADICALS; RESPIRATORY SYSTEM; SOMATIC CELLS 560300* -- Chemicals Metabolism & Toxicology