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Title: Effects of cigarette smoking on metabolic events in the lung

Abstract

Nicotine and cigarette smoke extract show acute physiological effects: increasing tracheal pressure (P/sub TR/), pulmonary artery pressure (P/sub PA/), systemic blood pressure (P/sub SYST/), and left atrium pressure (P/sub LA/); and decreasing cardiac output (Q/sub AORTA/) and blood flow to the left lower lobe (Q/sub LLL/). In addition, cigarette smoking induces bronchoconstriction, thus decreasing peak flow, FVC, and FEV/sub 1.0/ in healthy subjects. It has also been demonstrated that cigarette smoking caused temporary slowing of mucociliary clearance in the lung and that cigarette smoke increases the activity of aryl hydrocarbon hydroxylase which metabolizes benzo(..cap alpha..)pyrene. The authors demonstrated that serum angiotensin I converting enzyme (ACE) activity showed a significant increase immediately after smoking and returned to the control level 20 min after smoking. They also demonstrated that plasma histamine levels showed a marked decrease after smoking. Furthermore, the effects of cigarette smoke and related substances on prostaglandin, thromboxane, testosterone, cyclic nucleotides metabolism, and protein synthesis were also investigated.

Authors:
Publication Date:
Research Org.:
Jichi Medical School, Tochigi, Japan
OSTI Identifier:
6016381
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 72
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZOPYRENE; METABOLISM; LUNGS; PHYSIOLOGY; TOBACCO SMOKES; BIOLOGICAL EFFECTS; BLOOD FLOW; BLOOD PRESSURE; ENZYME ACTIVITY; HYDROXYLASES; LUNG CLEARANCE; NICOTINE; NUCLEOTIDES; PROSTAGLANDINS; SEROTONIN; TESTOSTERONE; AEROSOLS; ALKALOIDS; AMINES; ANDROGENS; ANDROSTANES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZINES; AZOLES; BODY; CLEARANCE; COLLOIDS; CONDENSED AROMATICS; DISPERSIONS; DRUGS; ENZYMES; EXCRETION; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROCARBONS; HYDROXY COMPOUNDS; INDOLES; KETONES; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXIDOREDUCTASES; PARASYMPATHOLYTICS; PARASYMPATHOMIMETICS; PYRIDINES; PYRROLES; PYRROLIDINES; RADIOPROTECTIVE SUBSTANCES; RESIDUES; RESPIRATORY SYSTEM; SMOKES; SOLS; STEROID HORMONES; STEROIDS; SYMPATHOMIMETICS; TRYPTAMINES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Kitamura, S. Effects of cigarette smoking on metabolic events in the lung. United States: N. p., 1987. Web. doi:10.1289/ehp.8772283.
Kitamura, S. Effects of cigarette smoking on metabolic events in the lung. United States. https://doi.org/10.1289/ehp.8772283
Kitamura, S. 1987. "Effects of cigarette smoking on metabolic events in the lung". United States. https://doi.org/10.1289/ehp.8772283.
@article{osti_6016381,
title = {Effects of cigarette smoking on metabolic events in the lung},
author = {Kitamura, S},
abstractNote = {Nicotine and cigarette smoke extract show acute physiological effects: increasing tracheal pressure (P/sub TR/), pulmonary artery pressure (P/sub PA/), systemic blood pressure (P/sub SYST/), and left atrium pressure (P/sub LA/); and decreasing cardiac output (Q/sub AORTA/) and blood flow to the left lower lobe (Q/sub LLL/). In addition, cigarette smoking induces bronchoconstriction, thus decreasing peak flow, FVC, and FEV/sub 1.0/ in healthy subjects. It has also been demonstrated that cigarette smoking caused temporary slowing of mucociliary clearance in the lung and that cigarette smoke increases the activity of aryl hydrocarbon hydroxylase which metabolizes benzo(..cap alpha..)pyrene. The authors demonstrated that serum angiotensin I converting enzyme (ACE) activity showed a significant increase immediately after smoking and returned to the control level 20 min after smoking. They also demonstrated that plasma histamine levels showed a marked decrease after smoking. Furthermore, the effects of cigarette smoke and related substances on prostaglandin, thromboxane, testosterone, cyclic nucleotides metabolism, and protein synthesis were also investigated.},
doi = {10.1289/ehp.8772283},
url = {https://www.osti.gov/biblio/6016381}, journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 72,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 1987},
month = {Mon Jun 01 00:00:00 EDT 1987}
}