Perinatal upregulation of intestinal transport of carnitine (C) in newborn pigs

Conference · Mon Feb 26 00:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6011631

Li, B U.K.; Murray, R D; Heitlinger, L A; McClung, H J; Hughes, A M; O'Dorisio, T M; Sloan, H R ^[1]

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1. Columbus Children's Hospital, OH (United States) Ohio State Univ., Columbus (United States)

Since C facilitates the perinatal transition from carbohydrate to lipid-derived energy, the authors examined the contribution of intestinal transport of dietary C to this process by determining (C)'s in sow's milk, pig jejunum and liver, and C flux across the jejunum (J{sub m-s}) as a function of postnatal age. The authors measured portal venous glucagon (G) and insulin (l) as potential regulatory signals and attempted to alter intestinal transport of C by infusing G. Pigs at days 1-7 (NB-newborn), 14-16 (SU-suckling) and 33-35 (WN-weanling) were studied. (C)'s in sow milk, piglet jejunum, and liver were determined. Fluxes were measured in an Ussing chamber and in an in situ recirculating jejunal perfusion. The effect of an IV infusion of G on ({sup 3}H)C absorption was evaluated in a single animal; an adjacent jejunal segment received saline. Sow's milk and liver (C)'s, and jejunal C transport were highest following birth and declined towards weaning. Plasma (G) and the G:I ratio demonstrated a parallel temporal pattern. The G-stimulated jejunal segment removed 53% of the C and the non-stimulated control segment, 8%. It was concluded that during the perinatal metabolic transition, enhanced intestinal nutrient assimilation promotes the transfer of dietary C to the liver where it could facilitate fatty acid oxidation. This pattern of upregulated intestinal transport immediately after birth may be mediated by pancreatic G and I secretion.

• OSTI ID: 6011631
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 4:3; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARNITINE
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
LIVER
METABOLISM
MILK
OXIDATION
SMALL INTESTINE
SWINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINO ACIDS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
FOOD
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
HYDROXY ACIDS
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
VERTEBRATES
VITAMIN B GROUP
VITAMINS
550201* - Biochemistry- Tracer Techniques