Dynamic study of rectally absorbed ammonia in liver cirrhosis using (13N)ammonia and a positron camera
(13N)Ammonia produced by the cyclotron was instilled intrarectally in patients with cirrhosis and other liver diseases to study the turnover of rectally absorbed (12N)ammonia. In the control, (13N)ammonia was absorbed quickly and visualized the liver, whereas in patients with cirrhosis, the lungs and heart were first visualized, and 13N activity over the head was also higher. It was suggested that a large proportion of absorbed (13N)ammonia bypassed hepatocytes and reached peripheral tissues in cirrhosis. The heart/liver ratio of 13N and 13N over the head were correlated with various indices of portal hypertension. The relative proportion of nonammonia 13N metabolites in blood was lower at 5 and 15 min after administration in cirrhosis, suggesting a reduced capacity of the liver to remove and metabolize ammonia.
- OSTI ID:
- 6007683
- Journal Information:
- Dig. Dis. Sci.; (United States), Vol. 25:11
- Country of Publication:
- United States
- Language:
- English
Similar Records
Hepatic venography in noncirrhotic idiopathic portal hypertension: comparison with cirrhosis of the liver
Cirrhosis could be associated with severe mutations of the cystic fibrosis gene
Related Subjects
AMMONIA
METABOLISM
TISSUE DISTRIBUTION
BLOOD
RADIONUCLIDE KINETICS
HEART
LIVER
NITROGEN 13
LIVER CIRRHOSIS
PATIENTS
POSITRON CAMERAS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GAMMA CAMERAS
GLANDS
HYDRIDES
HYDROGEN COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MATERIALS
MINUTES LIVING RADIOISOTOPES
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)