Calcium flux and metabolism in the pigeon heart following doxorubicin treatment: an acute study

Conference · Thu Jan 01 00:00:00 EST 1981

OSTI ID:6007162

Revis, N

The present studies were performed to determine in vivo the initial and secondary acute effects of doxorubicin on the influx of calcium into myocardial cells. Studies are also described showing the effect of doxorubicin on a calcium-activated neutral protease from cardiac tissue. These latter studies were performed in an attempt to explain the loss of myofibrilular structures in myocardial cells following doxorubicin treatment.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6007162
• Report Number(s): CONF-810991-1; ON: DE82002822
• Resource Relation: Conference: International symposium on present and future status of the anthracycline antibiotics in cancer, New York, NY, USA, 16 Sep 1981
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CALCIUM
METABOLISM
CELL MEMBRANES
PERMEABILITY
DOXORUBICIN
BIOLOGICAL EFFECTS
CHELATES
ENZYMES
EXPERIMENTAL DATA
IN VIVO
MITOCHONDRIA
MYOCARDIUM
PIGEONS
ALKALINE EARTH METALS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BIRDS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
COMPLEXES
DATA
DRUGS
ELEMENTS
HEART
INFORMATION
MEMBRANES
METALS
MUSCLES
NUMERICAL DATA
ORGANOIDS
ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)