Increased folate uptake prevents dietary development of folate deficiency in the rat brain
Abstract
Folic acid and folate deficiency have been implicated in disorders of the central nervous system. In a study of the mechanism for the effects of chronic ethanol on folate homeostasis, the uptake of {sup 3}H-folic acid by the rat brain has been studied. Male Sprague-Dawley rats were fed sulfonamide-supplemented folate-sufficient and folate-deficient liquid diets containing either ethanol or isoenergic carbohydrate as a control. After 16 weeks, severe folate depletion occurred in tissues (liver, kidney, spleen, lung intestine, testes), but not in the brain. Tissue retention of {sup 3}H-folic acid was increased four-fold in the brain of folate-deficient rats. A smaller increase in uptake was observed in the other tissues, except for the liver, in which the retention of {sup 3}H-folic acid was slightly decreased. Chronic ethanol feeding decreased hepatic folate uptake, but not that by the increase the uptake of folate from the plasma of folate-deficient rats, thereby inhibiting the development of brain folate deficiency.
- Authors:
-
- Louisiana State Univ., Shreveport (United States)
- Publication Date:
- OSTI Identifier:
- 6006315
- Report Number(s):
- CONF-9104107-
Journal ID: ISSN 0892-6638; CODEN: FAJOE
- Resource Type:
- Conference
- Journal Name:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
- Additional Journal Information:
- Journal Volume: 4:3; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; Journal ID: ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ETHANOL; TOXICITY; FOLIC ACID; BIOCHEMICAL REACTION KINETICS; ANIMAL TISSUES; BRAIN; INTESTINES; KIDNEYS; LIVER; LUNGS; NUTRITIONAL DEFICIENCY; RETENTION; SPLEEN; TESTES; TRACER TECHNIQUES; TRITIUM COMPOUNDS; UPTAKE; ALCOHOLS; AMINO ACIDS; AROMATICS; AZAARENES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; GLANDS; GONADS; HEMATINICS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; KINETICS; MALE GENITALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PTERIDINES; REACTION KINETICS; RESPIRATORY SYSTEM; TISSUES; VITAMIN B GROUP; VITAMINS; 560300* - Chemicals Metabolism & Toxicology; 550201 - Biochemistry- Tracer Techniques
Citation Formats
McMartin, K E, Collins, T D, Eisenga, B H, and Bhandari, S D. Increased folate uptake prevents dietary development of folate deficiency in the rat brain. United States: N. p., 1990.
Web.
McMartin, K E, Collins, T D, Eisenga, B H, & Bhandari, S D. Increased folate uptake prevents dietary development of folate deficiency in the rat brain. United States.
McMartin, K E, Collins, T D, Eisenga, B H, and Bhandari, S D. 1990.
"Increased folate uptake prevents dietary development of folate deficiency in the rat brain". United States.
@article{osti_6006315,
title = {Increased folate uptake prevents dietary development of folate deficiency in the rat brain},
author = {McMartin, K E and Collins, T D and Eisenga, B H and Bhandari, S D},
abstractNote = {Folic acid and folate deficiency have been implicated in disorders of the central nervous system. In a study of the mechanism for the effects of chronic ethanol on folate homeostasis, the uptake of {sup 3}H-folic acid by the rat brain has been studied. Male Sprague-Dawley rats were fed sulfonamide-supplemented folate-sufficient and folate-deficient liquid diets containing either ethanol or isoenergic carbohydrate as a control. After 16 weeks, severe folate depletion occurred in tissues (liver, kidney, spleen, lung intestine, testes), but not in the brain. Tissue retention of {sup 3}H-folic acid was increased four-fold in the brain of folate-deficient rats. A smaller increase in uptake was observed in the other tissues, except for the liver, in which the retention of {sup 3}H-folic acid was slightly decreased. Chronic ethanol feeding decreased hepatic folate uptake, but not that by the increase the uptake of folate from the plasma of folate-deficient rats, thereby inhibiting the development of brain folate deficiency.},
doi = {},
url = {https://www.osti.gov/biblio/6006315},
journal = {FASEB Journal (Federation of American Societies for Experimental Biology); (United States)},
issn = {0892-6638},
number = ,
volume = 4:3,
place = {United States},
year = {Mon Feb 26 00:00:00 EST 1990},
month = {Mon Feb 26 00:00:00 EST 1990}
}