Response of lymphosarcoma LS/BL cells to continuous irradiation
Mouse lymphosarcoma LS/BL cells growing as an ascites tumor in the peritoneal cavity of C57BL mice were continuously irradiated in vivo at a low exposure rate of 1.2 Gy per day (5 rad/hr). The growth of the ascites tumor evaluated by direct counting of the cells in the peritoneal cavity and their capacity to form colonies in livers declined with increasing time of continuous irradiation. The radiosensitivity and repair ability of LS/BL cells were studied by a serial dilution method using host survival time as the end point and by the liver colony assay. The radiosensitivity of continuously irradiated LS/BL-CI cells showed no remarkable change as measured by the D/sub 0/ values, but from the 150th week of irradiation the inital shoulder on the survival curves appeared and its width increased with time of exposure. The extrapolation number (n) increased from 1.0 to 8.4 after 350 weeks of irradiation. The reappearance of the initial shoulder was proved with the split-dose technique.
- Research Organization:
- Inst. of Biophysics, Brno, Czechoslovakia
- OSTI ID:
- 6004239
- Journal Information:
- Radiat. Res.; (United States), Vol. 100:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ASCITES TUMOR CELLS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
RADIOINDUCTION
CHRONIC IRRADIATION
RADIOSENSITIVITY EFFECTS
BIOLOGICAL REPAIR
COLONY FORMATION
EXPERIMENTAL DATA
LYMPHOSARCOMAS
MICE
SURVIVAL CURVES
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
CHRONIC EXPOSURE
DATA
DISEASES
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LYMPHOMAS
MAMMALS
NEOPLASMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RODENTS
SARCOMAS
TUMOR CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)
560152 - Radiation Effects on Animals- Animals